Paul L Ornstein, Ph.D.
Affiliations: | 1984-2012 | Discovery Chemistry | Eli Lilly & Co |
| 2012-2017 | College of Pharmacy | Roosevelt University, Chicago, IL, United States | |
| 2016- | Apollod Drug Discovery Consulting | ||
| 2017-2019 | School of Pharmacy | Medical College of Wisconsin, Millwauke, Wauwatosa, WI, United States |
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Parents
Sign in to add mentor| Barry M. Trost | grad student | 1977-1982 | UW Madison |
| David A. Evans | post-doc | 1982-1984 |
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Publications
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| Hembre E, Early JV, Odingo J, et al. (2021) Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against . Frontiers in Chemistry. 9: 613349 |
| Knopp KL, Simmons RMA, Guo W, et al. (2019) Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics |
| Zuniga ES, Korkegian A, Mullen S, et al. (2017) The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents. Bioorganic & Medicinal Chemistry |
| Witkin JM, Mitchell S, Wafford K, et al. (2017) Comparative Effects of LY3020371, a Potent and Selective mGlu2/3 Receptor Antagonist, and Ketamine, a Non-Competitive NMDA Receptor Antagonist, in Rodents: Evidence Supporting Use for the Treatment of Depression. The Journal of Pharmacology and Experimental Therapeutics |
| Chappell MD, Li R, Smith SC, et al. (2016) Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. Journal of Medicinal Chemistry. 59: 10974-10993 |
| Dressman BA, Tromiczak EG, Chappell MD, et al. (2016) Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorganic & Medicinal Chemistry Letters |
| Kato AS, Burris KD, Gardinier KM, et al. (2016) Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine |
| Gardinier KM, Gernert DL, Porter WJ, et al. (2016) The Discovery of The First α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent Upon Transmembrane AMPA Receptor Regulatory Protein (TARP) Gamma-8. Journal of Medicinal Chemistry |
| Witkin JM, Ornstein PL, Mitch CH, et al. (2015) In Vitro Pharmacological and Rat Pharmacokinetic Characterization of LY3020371, a Potent and Selective mGlu2/3 Receptor Antagonist. Neuropharmacology |
| Martinez-Perez JA, Iyengar S, Shannon HE, et al. (2013) GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorganic & Medicinal Chemistry Letters. 23: 6463-6 |