Christie Brouillette
Affiliations: | Chemistry | University of Alabama, Birmingham, Birmingham, AL, United States |
Area:
Protein Structural Cooperativity and Energetics, Biophysics, Antibacterial Drug DiscoveryWebsite:
https://www.uab.edu/csb/faculty/christie-brouilletteGoogle:
"Christie Brouillette"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Mathias P. Mertes | grad student | 1979 | University of Kansas | |
| (The design and synthesis of potentially specific DNA binding agents (part I) : deoxyuridine analogs as inhibitors of thymidylate synthetase (part II).) | ||||
BETA: Related publications
See more...
Publications
|
You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect. |
| Moro WB, Yang Z, Kane TA, et al. (2009) SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25 |
| Moro WB, Yang Z, Kane TA, et al. (2009) Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5 |
| McDonald HM, Pruett PS, Deivanayagam C, et al. (2007) Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis. Acta Crystallographica. Section D, Biological Crystallography. 63: 891-905 |
| Velu SE, Mou L, Luan CH, et al. (2007) Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21 |
| Velu SE, Luan CH, Delucas LJ, et al. (2005) Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904 |
| Protasevich II, Brouillette CG, Snow ME, et al. (2004) Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. Biochemistry. 43: 13380-9 |
| Yang ZW, Tendian SW, Carson WM, et al. (2004) Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase. Protein Science : a Publication of the Protein Society. 13: 830-41 |
| Chesnokova LS, Slepenkov SV, Protasevich II, et al. (2003) Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis. Biochemistry. 42: 9028-40 |
| Velu SE, Cristofoli WA, Garcia GJ, et al. (2003) Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81 |
| Devedjiev Y, Symersky J, Singh R, et al. (2001) Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 57: 806-12 |