Michael Webb

Leeds, Apollo, PA, United States 
"Michael Webb"
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Ross JF, Wildsmith GC, Johnson M, et al. (2019) Directed assembly of homo-pentameric cholera toxin B-subunit proteins into higher-order structures using coiled-coil appendages. Journal of the American Chemical Society
Arnott Z, Nozaki S, Monteiro D, et al. (2017) Mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ.AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan). Biochemistry
Monteiro DC, Patel V, Bartlett CP, et al. (2015) The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. Chemistry & Biology. 22: 492-503
Monteiro DCF, Patel V, Bartlett CP, et al. (2015) Towards a generalised approach for the time-resolved crystallographic study of enzymes Acta Crystallographica Section a Foundations and Advances. 71: s25-s25
Webb ME, Yorke BA, Kershaw T, et al. (2014) Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1166-72
Pearson A, Polyakova A, Yorke BA, et al. (2013) Developing a set of complementary methods for time-resolved structural studies Acta Crystallographica Section a Foundations of Crystallography. 69: s282-s282
Monteiro DC, Rugen MD, Shepherd D, et al. (2012) Formation of a heterooctameric complex between aspartate α-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent. Biochemical and Biophysical Research Communications. 426: 350-5
Webb ME, Lobley CM, Soliman F, et al. (2012) Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 414-7
Cheng H, Hwang I, Chong Y, et al. (2005) Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 13: 3593-9
Webb ME, Smith AG, Abell C. (2005) Biosynthesis of Pantothenate Cheminform. 36
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