Christopher J Dinsmore

"Christopher Dinsmore"
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Thomas Robert Hoye grad student 1987-1991 UMN
David A. Evans post-doc 1991-1994 Harvard
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Wolkenberg SE, Nolt MB, Bilodeau MT, et al. (2017) Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorganic & Medicinal Chemistry Letters
Simov V, Deshmukh SV, Dinsmore CJ, et al. (2016) Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorganic & Medicinal Chemistry Letters
Siu T, Kumarasinghe SE, Altman MD, et al. (2014) The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization. Bioorganic & Medicinal Chemistry Letters. 24: 1466-71
Northrup AB, Katcher MH, Altman MD, et al. (2013) Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. Journal of Medicinal Chemistry. 56: 2294-310
Lim J, Taoka B, Otte RD, et al. (2011) Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. Journal of Medicinal Chemistry. 54: 7334-49
Katz JD, Jewell JP, Guerin DJ, et al. (2011) Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. Journal of Medicinal Chemistry. 54: 4092-108
Siu T, Kozina ES, Jung J, et al. (2010) The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead. Bioorganic & Medicinal Chemistry Letters. 20: 7421-5
Beshore DC, Liverton NJ, McIntyre CJ, et al. (2010) Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorganic & Medicinal Chemistry Letters. 20: 2493-6
Peterson SL, Stucka SM, Dinsmore CJ. (2010) Parallel synthesis of ureas and carbamates from amines and CO2 under mild conditions. Organic Letters. 12: 1340-3
Pan BS, Chan GK, Chenard M, et al. (2010) MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Research. 70: 1524-33
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