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Matthew W Boudreau, Ph.D.

Affiliations: 
2016-2022 Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 2022- Medical Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States 
Area:
Chemistry, Cancer Biology
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Parents

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Derek S. Tan research assistant 2015-2015 Memorial Sloan Kettering Cancer Center
Joshua G. Pierce research assistant 2012-2016 NCSU
Paul J. Hergenrother grad student 2016-2022 UIUC
William G. Kaelin post-doc 2022- Dana-Farber Cancer Institute and Harvard Medical School

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Publications

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Wang J, Su X, Jiang L, et al. (2023) Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers. 15
Jiang L, Liu Y, Tumbath S, et al. (2023) IP-DNQ induces mitochondrial dysfunction and G2/M phase cell cycle arrest to selectively kill NQO1-positive pancreatic cancer cells. Antioxidants & Redox Signaling
Boudreau MW, Tonogai EJ, Schane CP, et al. (2023) The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma. Melanoma Research
Ghosh S, Yang R, Duraki D, et al. (2023) Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis. Cancer Research. OF1-OF16
Boudreau MW, Hergenrother PJ. (2022) Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. Rsc Medicinal Chemistry. 13: 711-725
Boudreau MW, Mulligan MP, Shapiro DJ, et al. (2022) Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry
Boudreau MW, Duraki D, Wang L, et al. (2021) A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine. 13
Lundberg AP, Boudreau MW, Selting KA, et al. (2021) Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy. Neoplasia (New York, N.Y.). 23: 811-822
Duraki D, Boudreau MW, Wang L, et al. (2020) OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer Journal of the Endocrine Society. 4
Boudreau MW, Hergenrother PJ, Duraki D, et al. (2020) Abstract P5-05-16: Quantitative regression of estrogen receptor alpha positive breast cancer Cancer Research. 80
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