David H. T. Harrison

Affiliations: 
2003- Biochemistry & Molecular Biology Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States 
Area:
molecular recognition
Website:
https://www.rosalindfranklin.edu/academics/faculty/david-h-harrison/
Google:
"David H. T. Harrison"
Bio:

https://s3.amazonaws.com/rfums-bigtree/files/resources/harrison_cv_032814.pdf
https://www.researchgate.net/profile/David_Harrison14

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Parents

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Byron Herbert Rubin grad student 1983 Emory
 (M.S. thesis: X-ray Structure of an Anti-Herpes Pro-drug 2,2'-Anhydro1-β-D-arabinofuranosyl Thymine.)
Peter B. Moore grad student 1992 Yale
 (Neutron Scattering Studies on the E. coli 30S Ribosomal Subunit and its Components.)
Gregory A. Petsko post-doc 1993-1995 Brandeis
Dagmar Ringe post-doc 1993-1995 Brandeis
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Publications

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Aluvila S, Kotaria R, Sun J, et al. (2010) The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity. The Journal of Biological Chemistry. 285: 27314-26
Aluvila S, Sun J, Harrison DH, et al. (2010) Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor. Molecular Pharmacology. 77: 26-34
Remani S, Sun J, Kotaria R, et al. (2008) The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate. Journal of Bioenergetics and Biomembranes. 40: 577-85
Brownlee J, He P, Moran GR, et al. (2008) Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate. Biochemistry. 47: 2002-13
Theisen MJ, Misra I, Saadat D, et al. (2004) 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time". Proceedings of the National Academy of Sciences of the United States of America. 101: 16442-7
Brownlee JM, Johnson-Winters K, Harrison DH, et al. (2004) Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry. 43: 6370-7
Marks GT, Susler M, Harrison DH. (2004) Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change. Biochemistry. 43: 3802-13
Zhang X, Harrison DH, Cui Q. (2002) Functional specificities of methylglyoxal synthase and triosephosphate isomerase: a combined QM/MM analysis. Journal of the American Chemical Society. 124: 14871-8
Marks GT, Harris TK, Massiah MA, et al. (2001) Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy. Biochemistry. 40: 6805-18
Saadat D, Harrison DH. (2000) Mirroring perfection: the structure of methylglyoxal synthase complexed with the competitive inhibitor 2-phosphoglycolate. Biochemistry. 39: 2950-60
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