David Grahame Hardie

Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom 
Biochemistry, Cell Biology
"Hardie, David Grahame"


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Zong Y, Zhang CS, Li M, et al. (2019) Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research
Thomas EC, Hook SC, Gray A, et al. (2018) Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical Journal
Fyffe FA, Hawley SA, Gray A, et al. (2018) Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. Methods in Molecular Biology (Clifton, N.J.). 1732: 69-86
Zhang CS, Hawley SA, Zong Y, et al. (2017) Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature
Ross FA, Hawley SA, Auciello FR, et al. (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chemical Biology
Hawley SA, Ford RJ, Smith BK, et al. (2016) The Na+/glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes
Fogarty S, Ross FA, Vara Ciruelos D, et al. (2016) AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2. Molecular Cancer Research : McR
Hardie DG, Schaffer BE, Brunet A. (2015) AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends in Cell Biology
Schneider H, Schubert KM, Blodow S, et al. (2015) AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension. 66: 108-16
Jensen TE, Ross FA, Kleinert M, et al. (2015) PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. The Biochemical Journal. 467: 461-72
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