Pradip K. Mascharak
Affiliations: | Chemistry & Biochemistry | University of California, Santa Cruz, Santa Cruz, CA, United States |
Area:
Inorganic Chemistry, Protein Active Site Modeling, Design and Syntheses of NO- and CO-donors, Green ChemistryWebsite:
http://mascharak.chem.ucsc.edu/Index.htmlGoogle:
"Pradip K Mascharak"Bio:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=pradip
Pradip K. Mascharak was born in Jaipur, India, in 1953. He received his Ph.D. from the Indian Institute of Technology, Kanpur, in 1979. In the same year, he joined the research group of Professor Richard Holm at Stanford University and later moved to Harvard University. He later worked with Professor Steve Lippard at the Massachusetts Institute of Technology for two years before joining the University of California, Santa Cruz (UCSC), in late 1984. He is currently a Professor of Chemistry and Biochemistry at UCSC. Modeling the active sites of metalloenzymes, design of complexes that exhibit oxygenase activity in the presence of peroxides and dioxygen, and syntheses of photoactive NO donors are the major focus of his research.
Mean distance: 7.01
Parents
Sign in to add mentorAnimesh Chakravorty | grad student | 1977-1979 | IIT Kanpur |
Richard Hadley Holm | post-doc | 1979-1982 | Stanford/Harvard |
Stephen James Lippard | post-doc | 1982-1984 | MIT |
Children
Sign in to add traineeEdgardo Farinas | grad student | 1997 | UC Santa Cruz |
Juan C. Noveron | grad student | 2000 | UC Santa Cruz |
Dana S. Marlin | grad student | 2001 | UC Santa Cruz |
John M. Rowland | grad student | 2002 | UC Santa Cruz |
Laurie A. Tyler | grad student | 2002 | UC Santa Cruz |
Todd C. Harrop | grad student | 2004 | UC Santa Cruz |
Raman K. Afshar | grad student | 2005 | UC Santa Cruz |
Joshua D. Deschamps | grad student | 2006 | UC Santa Cruz |
Michael J. Rose | grad student | 2009 | UC Santa Cruz |
Claudia H. Swanson | grad student | 2009 | UC Santa Cruz |
Nicole L. Fry | grad student | 2012 | UC Santa Cruz |
Miguel Nicolás Pinto | grad student | 2014-2019 | UC Santa Cruz |
Apurba Kumar Patra | post-doc | 2001-2004 | UC Santa Cruz |
Kaushik Ghosh | post-doc | 2002-2005 | UC Santa Cruz |
Publications
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Mascharak PK. (2022) Nitric oxide delivery platforms derived from a photoactivatable Mn(II) nitrosyl complex: Entry to photopharmacology. Journal of Inorganic Biochemistry. 231: 111804 |
Kawahara B, Faull KF, Janzen C, et al. (2021) Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel. Journal of Medicinal Chemistry |
Stenger-Smith J, Chakraborty I, Ouattara R, et al. (2021) CO release from Mn(I)-based photoCORMs with single photons in the phototherapeutic region. Chemical Communications (Cambridge, England) |
Mascharak P, Stenger-Smith J. (2020) Gold Drugs with {Au(PPh3)}+ moiety: Advantages and Medicinal Applications. Chemmedchem |
Stenger-Smith J, Kamariza M, Chakraborty I, et al. (2020) Enhanced Bactericidal Effects of Pyrazinamide Toward and upon Conjugation to a {Au(I)-triphenylphosphine} Moiety. Acs Omega. 5: 6826-6833 |
Kawahara B, Gao L, Cohn W, et al. (2020) Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates. Chemical Science. 11: 467-473 |
Kawahara B, Sen S, Mascharak PK. (2020) Reaction of carbon monoxide with cystathionine β-synthase: implications on drug efficacies in cancer chemotherapy. Future Medicinal Chemistry |
Pinto MN, Mascharak PK. (2020) Light-assisted and remote delivery of carbon monoxide to malignant cells and tissues: Photochemotherapy in the spotlight Journal of Photochemistry and Photobiology C: Photochemistry Reviews. 42: 100341 |
Pinto MN, Chakraborty I, Jimenez J, et al. (2019) Therapeutic Potential of Two Visible Light Responsive Luminescent photoCORMs: Enhanced Cellular Internalization Driven by Lipophilicity. Inorganic Chemistry |
deBoer TR, Palomino RI, Mascharak PK. (2019) Peroxynitrite-Mediated Dimerization of 3-Nitrotyrosine: Unique Chemistry along the Spectrum of Peroxynitrite-Mediated Nitration of Tyrosine. Med One. 4 |