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Pradip K. Mascharak

Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Inorganic Chemistry, Protein Active Site Modeling, Design and Syntheses of NO- and CO-donors, Green Chemistry
"Pradip K Mascharak"
Pradip K. Mascharak was born in Jaipur, India, in 1953. He received his Ph.D. from the Indian Institute of Technology, Kanpur, in 1979. In the same year, he joined the research group of Professor Richard Holm at Stanford University and later moved to Harvard University. He later worked with Professor Steve Lippard at the Massachusetts Institute of Technology for two years before joining the University of California, Santa Cruz (UCSC), in late 1984. He is currently a Professor of Chemistry and Biochemistry at UCSC. Modeling the active sites of metalloenzymes, design of complexes that exhibit oxygenase activity in the presence of peroxides and dioxygen, and syntheses of photoactive NO donors are the major focus of his research.

Mean distance: 7.01


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Animesh Chakravorty grad student 1977-1979 IIT Kanpur
Richard Hadley Holm post-doc 1979-1982 Stanford/Harvard
Stephen James Lippard post-doc 1982-1984 MIT


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Edgardo Farinas grad student 1997 UC Santa Cruz
Juan C. Noveron grad student 2000 UC Santa Cruz
Dana S. Marlin grad student 2001 UC Santa Cruz
John M. Rowland grad student 2002 UC Santa Cruz
Laurie A. Tyler grad student 2002 UC Santa Cruz
Todd C. Harrop grad student 2004 UC Santa Cruz
Raman K. Afshar grad student 2005 UC Santa Cruz
Joshua D. Deschamps grad student 2006 UC Santa Cruz
Michael J. Rose grad student 2009 UC Santa Cruz
Claudia H. Swanson grad student 2009 UC Santa Cruz
Nicole L. Fry grad student 2012 UC Santa Cruz
Miguel Nicolás Pinto grad student 2014-2019 UC Santa Cruz
Apurba Kumar Patra post-doc 2001-2004 UC Santa Cruz
Kaushik Ghosh post-doc 2002-2005 UC Santa Cruz
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Mascharak P, Stenger-Smith J. (2020) Gold Drugs with {Au(PPh3)}+ moiety: Advantages and Medicinal Applications. Chemmedchem
Stenger-Smith J, Kamariza M, Chakraborty I, et al. (2020) Enhanced Bactericidal Effects of Pyrazinamide Toward and upon Conjugation to a {Au(I)-triphenylphosphine} Moiety. Acs Omega. 5: 6826-6833
Kawahara B, Gao L, Cohn W, et al. (2020) Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates. Chemical Science. 11: 467-473
Kawahara B, Sen S, Mascharak PK. (2020) Reaction of carbon monoxide with cystathionine β-synthase: implications on drug efficacies in cancer chemotherapy. Future Medicinal Chemistry
Pinto MN, Chakraborty I, Jimenez J, et al. (2019) Therapeutic Potential of Two Visible Light Responsive Luminescent photoCORMs: Enhanced Cellular Internalization Driven by Lipophilicity. Inorganic Chemistry
deBoer TR, Palomino RI, Mascharak PK. (2019) Peroxynitrite-Mediated Dimerization of 3-Nitrotyrosine: Unique Chemistry along the Spectrum of Peroxynitrite-Mediated Nitration of Tyrosine. Med One. 4
Kawahara B, Ramadoss S, Chaudhuri G, et al. (2018) Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. Journal of Inorganic Biochemistry. 191: 29-39
Hong S, Yan JJ, Karmalkar DG, et al. (2018) A mononuclear nonheme {FeNO} complex: synthesis and structural and spectroscopic characterization. Chemical Science. 9: 6952-6960
Stenger-Smith J, Chakraborty I, Mascharak PK. (2018) Cationic Au(I) complexes with aryl-benzothiazoles and their antibacterial activity. Journal of Inorganic Biochemistry. 185: 80-85
Pinto MN, Martinez-Gonzalez J, Chakraborty I, et al. (2018) Incorporation of a Theranostic "Two-Tone" Luminescent Silver Complex into Biocompatible Agar Hydrogel Composite for the Eradication of ESKAPE Pathogens in a Skin and Soft Tissue Infection Model. Inorganic Chemistry
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