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Marcia E. Newcomer

Biological Sciences Louisiana State University, Baton Rouge, LA, United States 
structural biology
"Marcia E. Newcomer"
Newcomer joined the Department of Biochemistry at Vanderbilt in 1989 as Assistant Professor and rose rapidly to become Professor in 1999. She had received her Ph.D. at Rice in crystallography with Quiocho. She worked with Wayne Anderson to establish the Vanderbilt crystallography laboratory and undertook several structural studies including approaches to the structure and function of retinol binding proteins with Dave Ong and others. In 2002, she accepted a position at Louisiana State University at Baton Rouge.

Mean distance: 8.46


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Florante A. Quiocho grad student 1979 Rice University
 (The binding of sugars to the l-arabinose-binding protein from Escherichia coli)
Gerald L. Hazelbauer research scientist 1985-1989 Louisiana State University Baton Rouge


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Audrey L. Lamb grad student 1998 Vanderbilt
Michael L. Oldham grad student 1998-2004 Vanderbilt
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Mathes F, Gilbert N, Newcomer M. (2022) Non-Competitive Inhibition by a Substrate Mimetic of Human 5-Lipoxygenase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology
Gilbert NC, Gerstmeier J, Schexnaydre EE, et al. (2020) Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nature Chemical Biology
Newcomer ME. (2019) Chloride to the rescue. The Journal of Biological Chemistry. 294: 11402-11403
Pakhomova S, Boeglin WE, Neau DB, et al. (2019) An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Science : a Publication of the Protein Society
Schexnaydre EE, Gerstmeier J, Garscha U, et al. (2018) A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
Gilbert NC, Neau DB, Newcomer ME. (2018) Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. Methods in Enzymology. 605: 33-49
Kodani SD, Bhakta S, Hwang SH, et al. (2018) Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters
Wang C, Pakhomova S, Newcomer ME, et al. (2017) Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. Plos One. 12: e0187169
Mashhadi Z, Newcomer ME, Brash AR. (2016) The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides. Chembiochem : a European Journal of Chemical Biology
Bender G, Schexnaydre EE, Murphy RC, et al. (2016) Membrane-dependent Activities of Human 15-LOX-2 and its Murine Counterpart: Implications for Murine Models of Atherosclerosis. The Journal of Biological Chemistry
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