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Marcia E. Newcomer

Affiliations: 
Biological Sciences Louisiana State University, Baton Rouge, LA, United States 
Area:
structural biology
Website:
http://www.biology.lsu.edu/cos/biosci/FacultyandStaff/Faculty/item40786.html
Google:
"Marcia E. Newcomer"
Bio:

http://hdl.handle.net/1911/15571
Newcomer joined the Department of Biochemistry at Vanderbilt in 1989 as Assistant Professor and rose rapidly to become Professor in 1999. She had received her Ph.D. at Rice in crystallography with Quiocho. She worked with Wayne Anderson to establish the Vanderbilt crystallography laboratory and undertook several structural studies including approaches to the structure and function of retinol binding proteins with Dave Ong and others. In 2002, she accepted a position at Louisiana State University at Baton Rouge.

Mean distance: 8.46
 
SNBCP

Parents

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Florante A. Quiocho grad student 1979 Rice University
 (The binding of sugars to the l-arabinose-binding protein from Escherichia coli)

Children

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Audrey L. Lamb grad student 1998 Vanderbilt
Michael L. Oldham grad student 1998-2004 Vanderbilt
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Publications

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Pakhomova S, Boeglin WE, Neau DB, et al. (2019) An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Science : a Publication of the Protein Society
Lee KSS, Liu JY, Wagner KM, et al. (2018) Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. Journal of Medicinal Chemistry
Kodani SD, Bhakta S, Hwang SH, et al. (2018) Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters
Wang C, Pakhomova S, Newcomer ME, et al. (2017) Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. Plos One. 12: e0187169
Mashhadi Z, Newcomer ME, Brash AR. (2016) The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides. Chembiochem : a European Journal of Chemical Biology
Mitra S, Bartlett SG, Newcomer ME. (2015) Identification of the Substrate Access Portal of 5-Lipoxygenase. Biochemistry
Newcomer ME, Brash AR. (2015) The structural basis for specificity in lipoxygenase catalysis. Protein Science : a Publication of the Protein Society. 24: 298-309
Neau DB, Bender G, Boeglin WE, et al. (2014) Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. The Journal of Biological Chemistry. 289: 31905-13
Lee KS, Liu JY, Wagner KM, et al. (2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. Journal of Medicinal Chemistry. 57: 7016-30
Luka Z, Pakhomova S, Loukachevitch LV, et al. (2014) Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate Biochemical and Biophysical Research Communications. 449: 392-398
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