Paul C. Sternweis

Pharmacology University of Texas Southwestern Medical Center, Dallas, TX, United States 
 1977-1982 University of Virginia, Charlottesville, VA 
"Paul C. Sternweis"

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Leon A. Heppel grad student 1978 Cornell
 (The delta and epsilon subunits of the proton translocating ATPase from Escherichia coli: isolation, characterization and reconstitution)
Alfred G. Gilman post-doc 1977-1982 UVA
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Chen Z, Gutowski S, Sternweis PC. (2018) Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data in Brief. 17: 356-362
Dada O, Gutowski S, Brautigam CA, et al. (2017) Direct Regulation of p190RhoGEF by Activated Rho and Rac GTPases. Journal of Structural Biology
Pascoe HG, Gutowski S, Chen H, et al. (2015) Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF. Proceedings of the National Academy of Sciences of the United States of America. 112: 14852-7
Carter AM, Gutowski S, Sternweis PC. (2014) Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs). The Journal of Biological Chemistry. 289: 19737-46
Medina F, Carter AM, Dada O, et al. (2013) Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins Journal of Biological Chemistry. 288: 11325-11333
Chen Z, Guo L, Hadas J, et al. (2012) Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. The Journal of Biological Chemistry. 287: 25490-500
Chen Z, Guo L, Sprang SR, et al. (2011) Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. Protein Science : a Publication of the Protein Society. 20: 107-17
Chen Z, Medina F, Liu MY, et al. (2010) Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. The Journal of Biological Chemistry. 285: 21070-81
Callender HL, Horn MA, DeCamp DL, et al. (2010) Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage Journal of Theoretical Biology. 262: 679-690
Wall EA, Zavzavadjian JR, Chang MS, et al. (2009) Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Science Signaling. 2: ra28
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