Stephen P. Bell

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Biochemistry, Molecular Biology
Website:
https://biology.mit.edu/people/stephen_bell
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"Stephen P. Bell"
Bio:

http://science.mit.edu/research/faculty/bell-stephen-p
http://www.hhmi.org/scientists/stephen-p-bell
https://books.google.com/books?id=zGVLAQAAMAAJ
Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Dr. Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMB–Schering Plough Scientific Achievement Award, the 1998 Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT and the 2006 MIT School of Science Teaching Award.
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SNBCP

Parents

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Robert Tjian grad student 1990 UC Berkeley
 (Mechanisms of species specific transcriptional initiation by RNA Polymerase I)
Bruce W. Stillman post-doc CSHL

Children

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Paritosh Gangaramani grad student 2016- MIT
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Publications

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Pike AM, Friend CM, Bell SP. (2023) Distinct RPA functions promote eukaryotic DNA replication initiation and elongation. Nucleic Acids Research
Zhang A, Friedman LJ, Gelles J, et al. (2023) Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305556120
Amasino AL, Gupta S, Friedman LJ, et al. (2023) Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221484120
Zhang A, Friedman LJ, Gelles J, et al. (2023) Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing. Biorxiv : the Preprint Server For Biology
Amasino A, Gupta S, Friedman LJ, et al. (2023) Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing. Biorxiv : the Preprint Server For Biology
Gupta S, Friedman LJ, Gelles J, et al. (2021) A helicase-tethered ORC flip enables bidirectional helicase loading. Elife. 10
De Jesus Kim L, Friedman LJ, Looke M, et al. (2021) DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7. Elife. 10
Champasa K, Blank C, Friedman LJ, et al. (2019) A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding. Elife. 8
Rios-Morales RY, Chan SH, Bell SP. (2019) Initiation-specific alleles of the Cdc45 helicase-activating protein. Plos One. 14: e0214426
Bell SP. (2019) Decision letter: A new class of disordered elements controls DNA replication through initiator self-assembly Elife
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