Adam R Offenbacher, Ph.D.

Affiliations: 
2013 Chemistry and Biochemistry Georgia Institute of Technology, Atlanta, GA 
 2013-2017 Chemistry University of California, Berkeley, Berkeley, CA 
 2017- Biochemistry East Carolina University, Greenville, NC, United States 
Website:
http://www.ecu.edu/cs-cas/chem/Adam-Offenbacher.cfm
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Parents

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Bridgette Anne Barry grad student 2010 Georgia Tech
 (Protein structural changes and tyrosyl radical-mediated electron transfer reactions in ribonucleotide reductase and model compounds.)
Judith Pollock Klinman post-doc 2013-2017 UC Berkeley
 (Soybean Lipoxygenase, HDX-MS)
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Publications

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Offenbacher AR, Sharma A, Doan PE, et al. (2020) The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States. Biochemistry
Offenbacher AR, Barry BA. (2020) A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase. The Journal of Physical Chemistry. B
Hu S, Offenbacher AR, Lu ED, et al. (2019) Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network. The Journal of Biological Chemistry
Zaragoza JPT, Nguy A, Minnetian N, et al. (2019) Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase. The Journal of Physical Chemistry. B
Kostenko A, Ray K, Iavarone AT, et al. (2019) Kinetic characterization of the C-H activation step for the lipoxygenase from the pathogenic fungus, M. oryzae: Impact of N-linked glycosylation. Biochemistry
Hu S, Offenbacher AR, Thompson EM, et al. (2019) Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. Journal of the American Chemical Society
Klinman JP, Offenbacher AR. (2018) Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects. Accounts of Chemical Research
Klinman JP, Offenbacher AR, Hu S. (2017) Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs. Journal of the American Chemical Society
Offenbacher AR, Iavarone AT, Klinman JP. (2017) Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase. The Journal of Biological Chemistry
Offenbacher AR, Hu S, Poss EM, et al. (2017) Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. Acs Central Science. 3: 570-579
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