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Simon Z Giroux

Affiliations: 
Vertex Pharmaceuticals, Boston, MA, United States 
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"Simon Giroux"
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Parents

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Stephen Hanessian grad student 2000-2006 Université de Montréal
Elias James Corey post-doc 2007-2009 Harvard

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Publications

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Wilson JC, Boyd MJ, Giroux S, et al. (2020) Application of a Dual Catalytic Nickel/Iridium-Based Photoredox Reaction to Synthesize 2-Alkyl--Arylindoles in a Continuous Flow. The Journal of Organic Chemistry
Gair JJ, Grey RL, Giroux S, et al. (2019) Palladium Catalyzed Hydrodefluorination of Fluoro-(hetero)arenes Organic Letters. 21: 2482-2487
Bissonnette NB, Boyd MJ, May GD, et al. (2018) C-H Functionalization of Heteroarenes Using Unactivated Alkyl Halides through Visible-Light Photoredox Catalysis under Basic Conditions. The Journal of Organic Chemistry
Giroux S, Bilimoria D, Cadilhac C, et al. (2015) Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers. Bioorganic & Medicinal Chemistry Letters. 25: 936-9
Henderson JA, Bilimoria D, Bubenik M, et al. (2015) Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency. Bioorganic & Medicinal Chemistry Letters. 25: 944-7
Henderson JA, Bilimoria D, Bubenik M, et al. (2015) Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores. Bioorganic & Medicinal Chemistry Letters. 25: 948-51
Giroux S, Xu J, Reddy TJ, et al. (2014) Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors. Acs Medicinal Chemistry Letters. 5: 240-3
Giroux S, Corey EJ. (2008) Enantioselective synthesis of a simple benzenoid analogue of glycinoeclepin A. Organic Letters. 10: 5617-9
Giroux S, Bethke A, Fielenbach N, et al. (2008) Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. Organic Letters. 10: 3643-5
Giroux S, Corey EJ. (2008) An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from beta-ergosterol. Organic Letters. 10: 801-2
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