Richard Warren Gross, M.D., Ph.D.
|1982-||Chemistry||Washington University, Saint Louis, St. Louis, MO|
Area:chemical biology of membranes in health and disease
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|Jenkins CM, Yang K, Liu G, et al. (2018) Cytochromeis an oxidative stress-activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the-1 vinyl-ether linkage. The Journal of Biological Chemistry|
|Malley KR, Koroleva O, Miller I, et al. (2018) The structure of iPLAβ reveals dimeric active sites and suggests mechanisms of regulation and localization. Nature Communications. 9: 765|
|Moon SH, Liu X, Cedars AM, et al. (2017) Heart failure-induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. The Journal of Biological Chemistry|
|Liu GY, Moon SH, Jenkins CM, et al. (2017) The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin integrating mitochondrial bioenergetics and signaling. The Journal of Biological Chemistry|
|Liu X, Moon SH, Jenkins CM, et al. (2016) Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways. Cell Chemical Biology|
|Yang K, Dilthey BG, Gross RW. (2016) A Shotgun Lipidomics Approach to Stabilize the Regiospecificity of Monoglycerides Using a Facile Low-Temperature Derivatization Enabling Their Definitive Identification and Quantitation. Analytical Chemistry|
|Moon SH, Mancuso DJ, Sims HF, et al. (2016) Cardiac myocyte-specific knockout of iPLA2γ decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size. The Journal of Biological Chemistry|
|Yao CH, Fowle-Grider R, Mahieu NG, et al. (2016) Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts. Cell Chemical Biology|
|Yang K, Jenkins CM, Dilthey B, et al. (2015) Multidimensional mass spectrometry-based shotgun lipidomics analysis of vinyl ether diglycerides. Analytical and Bioanalytical Chemistry. 407: 5199-210|
|Schweitzer GG, Chen Z, Gan C, et al. (2015) Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice. Journal of Lipid Research. 56: 848-58|