Lari Lehtiö, Ph.D
Affiliations: | University of Oulu, Oulu, Finland |
Area:
ADP-ribosylation: Structural & Chemical biology.Google:
"Lari Lehtiö"Mean distance: (not calculated yet)
Children
Sign in to add trainee| Sudarshan Narasimha Murthy | grad student | 2015-2020 | University of Oulu (Crystallography Tree) |
| Yashwanth Ashok | post-doc | University of Oulu | |
| Sudarshan Narasimha Murthy | post-doc | 2020-2021 | University of Oulu (Crystallography Tree) |
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Publications
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| Vela-Rodríguez C, Scarpulla I, Ashok Y, et al. (2023) Discovery of DTX3L inhibitors through a homogeneous FRET-based assay that monitors formation and removal of poly-ubiquitin chains. Slas Discovery : Advancing Life Sciences R & D |
| Murthy S, Nizi MG, Maksimainen MM, et al. (2023) [1,2,4]Triazolo[3,4-]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of Medicinal Chemistry |
| Brinch SA, Amundsen-Isaksen E, Espada S, et al. (2022) The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models. Cancer Research Communications. 2: 233-245 |
| Galera-Prat A, Alaviuhkola J, Alanen HI, et al. (2022) Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity. Protein Engineering, Design & Selection : Peds |
| Nizi MG, Maksimainen MM, Lehtiö L, et al. (2022) Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules. Journal of Medicinal Chemistry. 65: 7532-7560 |
| Roy A, Alhammad YM, McDonald P, et al. (2022) Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Antiviral Research. 105344 |
| Sherrill LM, Joya EE, Walker A, et al. (2022) Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain. Bioorganic & Medicinal Chemistry. 67: 116788 |
| Nizi MG, Maksimainen MM, Murthy S, et al. (2022) Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. European Journal of Medicinal Chemistry. 237: 114362 |
| Sherrill LM, Joya EE, Walker A, et al. (2022) Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain. Biorxiv : the Preprint Server For Biology |
| Roy A, Alhammad YM, McDonald P, et al. (2022) Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Biorxiv : the Preprint Server For Biology |