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John F. Domsic, Ph.D.

Affiliations: 
2009 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Biochemistry
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Robert McKenna grad student 2009 UF Gainesville
 (Structural studies of the catalytic mechanisms of two superfast metalloenzymes: The carbonic anhydrases and manganese superoxide dismutases.)

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Publications

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Qin J, Rajaratnam R, Feng L, et al. (2015) Development of organometallic S6K1 inhibitors. Journal of Medicinal Chemistry. 58: 305-14
Mohandas R, Sautina L, Beem E, et al. (2014) Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret. Experimental Cell Research. 326: 136-42
Domsic JF, Chen HS, Lu F, et al. (2013) Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA. Plos Pathogens. 9: e1003672
Venkatakrishnan B, Yarbrough J, Domsic J, et al. (2013) Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking. Journal of Virology. 87: 4974-84
Zimmerman S, Domsic JF, Tu C, et al. (2013) Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila. Archives of Biochemistry and Biophysics. 529: 11-7
Lu F, Tsai K, Chen HS, et al. (2012) Identification of host-chromosome binding sites and candidate gene targets for Kaposi's sarcoma-associated herpesvirus LANA. Journal of Virology. 86: 5752-62
Mikulski R, Domsic JF, Ling G, et al. (2011) Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5. Archives of Biochemistry and Biophysics. 516: 97-102
Fisher SZ, Kovalevsky AY, Domsic J, et al. (2010) Enzymes for carbon sequestration: neutron crystallographic studies of carbonic anhydrase. Acta Crystallographica. Section D, Biological Crystallography. 66: 1178-83
Robbins AH, Domsic JF, Agbandje-McKenna M, et al. (2010) Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis. Acta Crystallographica. Section D, Biological Crystallography. 66: 950-2
Domsic JF, Williams W, Fisher SZ, et al. (2010) Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry. 49: 6394-9
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