Dorothee Kern, Ph.D.

Affiliations: 
Biochemistry Brandeis University, Waltham, MA, United States 
Area:
enzymology, NMR
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"Dorothee Kern"
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SNBCP
Cross-listing: Telomere and Telomerase Tree

Parents

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Gunter S. Fischer grad student 1989-1994 Brandeis
David E. Wemmer post-doc 1995-1998 UC Berkeley

Children

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Daryl A. Bosco grad student 2004 Brandeis
Alexandra K. Gardino grad student 2005 Brandeis (Telomere and Telomerase Tree)
Vu T. Thai grad student 2007 Brandeis (Telomere and Telomerase Tree)
Wladimir Labeikovsky grad student 2008 Brandeis (Telomere and Telomerase Tree)
Janice Velos grad student 2009 Brandeis (Telomere and Telomerase Tree)
S. J. Kerns grad student 2010 Brandeis (Telomere and Telomerase Tree)
Dimitar V. Pachov grad student 2010 Brandeis (Telomere and Telomerase Tree)
Aleksandr Milshteyn grad student 2011 Brandeis (Telomere and Telomerase Tree)
Katherine Henzler-Wildman post-doc 2003-2008 Brandeis

Collaborators

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Douglas Lowell Theobald collaborator 2012- Brandeis (Evolution Tree)
BETA: Related publications

Publications

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Stiller JB, Otten R, Häussinger D, et al. (2022) Structure determination of high-energy states in a dynamic protein ensemble. Nature. 603: 528-535
Otten R, Pádua RAP, Bunzel HA, et al. (2020) How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science (New York, N.Y.)
Hoemberger M, Pitsawong W, Kern D. (2020) Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase. Proceedings of the National Academy of Sciences of the United States of America
Hadzipasic A, Wilson C, Nguyen V, et al. (2020) Ancient origins of allosteric activation in a Ser-Thr kinase. Science (New York, N.Y.). 367: 912-917
Stiller JB, Kerns SJ, Hoemberger M, et al. (2019) Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics. Nature Catalysis. 2: 726-734
Zorba A, Nguyen V, Koide A, et al. (2019) Allosteric modulation of a human protein kinase with monobodies. Proceedings of the National Academy of Sciences of the United States of America
Pádua RAP, Sun Y, Marko I, et al. (2018) Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nature Communications. 9: 4507
Pitsawong W, Buosi V, Otten R, et al. (2018) Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife. 7
Otten R, Liu L, Kenner LR, et al. (2018) Rescue of conformational dynamics in enzyme catalysis by directed evolution. Nature Communications. 9: 1314
Pitsawong W, Buosi V, Otten R, et al. (2018) Author response: Dynamics of human protein kinase Aurora A linked to drug selectivity Elife
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