Albert E. Schmelzer, Ph.D.

Affiliations: 
2001 Northwestern University, Evanston, IL 
Area:
Chemical Engineering, Biochemistry, Cell Biology
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William M. Miller grad student 2001 Northwestern
 (Effects of elevated osmolality and carbon dioxide on the glycosylation of neural cell adhesion molecule and monoclonal antibody: Osmoprotectant compounds as mitigating agents.)
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Publications

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Lee JH, Reier J, Heffner KM, et al. (2017) Production and Characterization of Active Recombinant Human Factor II with Consistent Sialylation. Biotechnology and Bioengineering
Martin RW, Majewska NI, Chen CX, et al. (2017) Development of a CHO-based Cell-free Platform for Synthesis of Active Monoclonal Antibodies. Acs Synthetic Biology
Chauhan G, Schmelzer AE. (2017) A novel cholesterol/lipid delivery system for murine myeloma cell lines. Biotechnology Progress. 33: 795-803
Luo H, Lee N, Wang X, et al. (2017) Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography. Journal of Chromatography. A
deZengotita VM, Abston LR, Schmelzer AE, et al. (2002) Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality. Biotechnology and Bioengineering. 78: 741-52
Schmelzer AE, Miller WM. (2002) Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content. Biotechnology Progress. 18: 346-53
deZengotita VM, Schmelzer AE, Miller WM. (2002) Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: intracellular pH, cell size, apoptosis, and metabolism. Biotechnology and Bioengineering. 77: 369-80
Schmelzer AE, Miller WM. (2002) Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO(2). Biotechnology and Bioengineering. 77: 359-68
Schmelzer AE, deZengotita VM, Miller WM. (2000) Considerations for osmolality measurement under elevated pCO(2): comparison of vapor pressure and freezing point osmometry. Biotechnology and Bioengineering. 67: 189-96
Zanghi JA, Schmelzer AE, Mendoza TP, et al. (1999) Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO(2) or pH. Biotechnology and Bioengineering. 65: 182-91
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