Michal Sheffer, Ph.D.

Affiliations: 
2012 Weizmann Institute of Science, Rehovot, Israel 
Area:
Oncology, Molecular Biology
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"Michal Sheffer"
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Parents

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Eytan Domany grad student 2012 Weizmann Institute
 (Implications of genomic instability in colorectal cancer.)
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Publications

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Tarannum M, Dinh K, Vergara J, et al. (2024) CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer. Science Advances. 10: eadn0881
Dufva O, Gandolfi S, Huuhtanen J, et al. (2023) Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers. Immunity. 56: 2816-2835.e13
de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, et al. (2023) Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer. 4: 754-773
Sheffer M, Lowry E, Beelen N, et al. (2021) Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. Nature Genetics
Dashevsky O, De Matos Simoes R, Shirasaki R, et al. (2020) Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms Blood. 136: 36-36
De Matos Simoes R, Shirasaki R, Tang H, et al. (2020) POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma Blood. 136: 18-19
Sheffer M, Mitsiades C. (2020) 36 Molecular events regulating solid tumor cell responses to natural killer cells Journal For Immunotherapy of Cancer. 8: A37-A37
De Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, et al. (2019) Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma Blood. 134: 4407-4407
Gandolfi S, Sheffer M, Dufva O, et al. (2019) Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights from Studies of Pooled DNA-Barcoded Cell Line Panels Blood. 134: 620-620
Shirasaki R, Gandolfi S, De Matos Simoes R, et al. (2019) Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins Blood. 134: 318-318
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