Ian C. Brett, Ph.D.

Affiliations: 
2012 Biochemistry and Structural Biology Stony Brook University, Stony Brook, NY, United States 
Area:
Biochemistry
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"Ian Brett"
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Parents

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Steven Owen Smith grad student 2012 SUNY Stony Brook
 (Transmembrane Domain Structure and Function in the Erythropoietin Receptor.)
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Publications

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Defour JP, Leroy E, Dass S, et al. (2023) Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers. Elife. 12
Defour JP, Itaya M, Gryshkova V, et al. (2013) Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 2540-5
Itaya M, Brett IC, Smith SO. (2012) Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 831: 333-57
Defour J, Itaya M, Gryshkova V, et al. (2012) Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515 Blood. 120: 3449-3449
Staerk J, Defour JP, Pecquet C, et al. (2011) Orientation-specific signalling by thrombopoietin receptor dimers. The Embo Journal. 30: 4398-413
Itaya M, Brett IC, Liu W, et al. (2009) Structure of the Transmembrane Dimer of gp55-P of the Spleen Focus Forming Virus and its Interaction with the Erythropoietin Receptor Biophysical Journal. 96: 336a
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