David J. Kast, Ph.D.

2010 Biochemistry, Molecular Bio, and Biophysics University of Minnesota, Twin Cities, Minneapolis, MN 
 2010-2017 Physiology University of Pennsylvania Perelman School of Medicine 
 2017- Cell Biology and Physiology Washington University School of Medicine, Saint Louis 
Biophysics, Biomechanics, Biochemistry
"David Kast"
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David Dale Thomas grad student 2010 UMN
 (Phosphorylation-induced structural changes in smooth muscle myosin.)
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Kast DJ, Dominguez R. (2019) IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration. Molecular Biology of the Cell. mbcE18090600
Kast DJ, Dominguez R. (2019) Mechanism of IRSp53 inhibition by 14-3-3. Nature Communications. 10: 483
Kast DJ, Dominguez R. (2017) The Cytoskeleton-Autophagy Connection. Current Biology : Cb. 27: R318-R326
Kast DJ, Dominguez R. (2015) WHAMM links actin assembly via the Arp2/3 complex to autophagy. Autophagy. 11: 1702-4
Kast DJ, Zajac AL, Holzbaur EL, et al. (2015) WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism. Current Biology : Cb. 25: 1791-7
Kast DJ, Zajac AL, Holzbaur ELF, et al. (2015) WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism Current Biology
Kast DJ, Yang C, Disanza A, et al. (2014) Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nature Structural & Molecular Biology. 21: 413-22
Boczkowska M, Rebowski G, Kast DJ, et al. (2014) Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nature Communications. 5: 3308
Turegun B, Kast DJ, Dominguez R. (2013) Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. The Journal of Biological Chemistry. 288: 35758-68
Disanza A, Bisi S, Winterhoff M, et al. (2013) CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. The Embo Journal. 32: 2735-50
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