Anthony G Coyne

University of Cambridge, Cambridge, England, United Kingdom 
Fragment-based drug discovery
"Anthony Coyne"
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Bedwell E, McCarthy WJ, Coyne AG, et al. (2022) Development of potent inhibitors by fragment-linking strategies. Chemical Biology & Drug Design
Thomas SE, McCarthy WJ, El Bakali J, et al. (2022) Structural Characterization of Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Frontiers in Molecular Biosciences. 9: 880432
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, et al. (2022) Discovery of Novel Inhibitors of Uridine Diphosphate--Acetylenolpyruvylglucosamine Reductase (MurB) from , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. Journal of Medicinal Chemistry
Frederickson M, Selvam IR, Evangelopoulos D, et al. (2022) A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). European Journal of Medicinal Chemistry. 230: 114105
Charoensutthivarakul S, Thomas SE, Curran A, et al. (2022) Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach. Acs Infectious Diseases
Scott DE, Francis-Newton NJ, Marsh ME, et al. (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology
Sabbah M, Mendes V, Vistal RG, et al. (2020) Correction to Fragment-Based Design of InhA Inhibitors. Journal of Medicinal Chemistry
Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, et al. (2020) Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases
Thomas SE, Whitehouse AJ, Brown K, et al. (2020) Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research
Sabbah M, Mendes V, Vistal RG, et al. (2020) Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry
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