Patrick Fadden

Pharmacology University of Virginia, Charlottesville, VA 
"Patrick Fadden"
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Fadden P, Huang KH, Veal JM, et al. (2010) Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. Chemistry & Biology. 17: 686-94
Rice JW, Veal JM, Barabasz A, et al. (2009) Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib. Oncology Research. 18: 229-42
Howard BA, Sempowski GD, Scearce RM, et al. (2008) Murine CD7 shares antigenic cross-reactivity with HSP-60. Hybridoma (2005). 27: 81-9
Chandarlapaty S, Sawai A, Ye Q, et al. (2008) SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 240-8
Steed PM, Fadden P, Hall S. (2006) A novel, selective, orally active, potent small molecule inhibitor of Hsp90 Journal of Clinical Oncology. 24: 13067-13067
Graves PR, Kwiek JJ, Fadden P, et al. (2002) Discovery of novel targets of quinoline drugs in the human purine binding proteome. Molecular Pharmacology. 62: 1364-72
Mothe-Satney I, Yang D, Fadden P, et al. (2000) Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. Molecular and Cellular Biology. 20: 3558-67
Fadden P, Haystead TA, Lawrence JC. (1998) Phosphorylation of the translational regulator, PHAS-I, by protein kinase CK2. Febs Letters. 435: 105-9
Brunn GJ, Fadden P, Haystead TA, et al. (1997) The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. The Journal of Biological Chemistry. 272: 32547-50
Lawrence JC, Fadden P, Haystead TA, et al. (1997) PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. Advances in Enzyme Regulation. 37: 239-67
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