S. Cyrus Khojasteh

Affiliations: 
2000 University of Washington, Seattle, Seattle, WA 
 2000- Genentech Inc., Oceanside, CA, United States 
Website:
https://www.gene.com/scientists/our-scientists/cyrus-khojasteh
Google:
"S. Cyrus Khojasteh"
Bio:

https://books.google.com/books?id=5I4vAQAAIAAJ

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Parents

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Sidney D. Nelson grad student 1998 University of Washington
 (Studies on metabolism and toxicity of menthofuran.)
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Publications

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Zhang D, Dragovich PS, Yu SF, et al. (2019) Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Zhang D, Hop CE, Patilea-Vrana G, et al. (2019) Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Khojasteh SC, Bumpus NN, Driscoll JP, et al. (2019) Biotransformation and Bioactivation Reactions - 2018 Literature Highlights. Drug Metabolism Reviews. 1-72
Zhang D, Fourie-O'Donohue A, Dragovich PS, et al. (2019) Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Ma Y, Cruz-Chuh JD, Khojasteh SC, et al. (2019) Carfilzomib is not an appropriate payload of antibody-drug conjugates as rapid inactivation by lysosomal enzymes. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Pei Z, Chen C, Chen J, et al. (2018) Exploration of Pyrrolobenzodiazepine(PBD)-dimers Containing Disulfide-based Prodrugs as Payloads for Antibody-Drug Conjugates. Molecular Pharmaceutics
Khojasteh SC, Miller GP, Mitra K, et al. (2018) Biotransformation and bioactivation reactions - 2017 literature highlights . Drug Metabolism Reviews. 1-35
Schadt S, Bister B, Chowdhury SK, et al. (2018) A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development Under the "Metabolites in Safety Testing" Regulatory Guidances. Drug Metabolism and Disposition: the Biological Fate of Chemicals
Zhang D, Le H, Cruz-Chuh JD, et al. (2018) Immolation of p-aminobenzyl ether linker and payload potency and stability determine the cell killing activity of antibody-drug conjugates with phenol-containing payloads. Bioconjugate Chemistry
Zhang D, Yu SF, Khojasteh SC, et al. (2018) Intratumoral Payload Concentration Correlates with the Activity of Antibody- Drug Conjugates. Molecular Cancer Therapeutics
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