Mark Adam Ditzler

Affiliations: 
NASA Ames Research Center, Mountain View, CA, United States 
Area:
RNA, Origin of life, Astrobiology
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"Mark Ditzler"
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Parents

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Nils G. Walter grad student 2004-2009 University of Michigan
 (Folding and conformational dynamics of the hairpin ribozyme and the spliceosome: Combining computational and experimental analyses.)
Donald H. Burke post-doc 2009-2012 University of Missouri - Columbia

Children

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Milena Popovic post-doc 2013-2015 NASA Ames Research Center (Biomechanics Tree)
James D Stephenson post-doc 2014-2016 NASA Ames Research Center
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Publications

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Plebanek A, Larnerd C, Popović M, et al. (2019) Big on Change, Small on Innovation: Evolutionary Consequences of RNA Sequence Duplication. Journal of Molecular Evolution
Stephenson JD, Popović M, Bristow TF, et al. (2016) Evolution of ribozymes in the presence of a mineral surface. Rna (New York, N.Y.)
Popovi? M, Fliss PS, Ditzler MA. (2015) In vitro evolution of distinct self-cleaving ribozymes in diverse environments. Nucleic Acids Research
Whatley AS, Ditzler MA, Lange MJ, et al. (2013) Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, "UCAA-motif" RNA Aptamers. Molecular Therapy. Nucleic Acids. 2: e71
Ditzler MA, Lange MJ, Bose D, et al. (2013) High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase. Nucleic Acids Research. 41: 1873-84
Ditzler MA, Bose D, Shkriabai N, et al. (2011) Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Nucleic Acids Research. 39: 8237-47
Abelson J, Blanco M, Ditzler MA, et al. (2010) Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nature Structural & Molecular Biology. 17: 504-12
Ditzler MA, Otyepka M, Sponer J, et al. (2010) Molecular dynamics and quantum mechanics of RNA: conformational and chemical change we can believe in. Accounts of Chemical Research. 43: 40-7
Ditzler MA, Sponer J, Walter NG. (2009) Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme. Rna (New York, N.Y.). 15: 560-75
Ditzler MA, Rueda D, Mo J, et al. (2008) A rugged free energy landscape separates multiple functional RNA folds throughout denaturation. Nucleic Acids Research. 36: 7088-99
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