Alexandre Gagnon, Ph.D.

Affiliations: 
Chemistry Université du Québec à Montréal 
Area:
Organic chemistry, medicinal chemistry, organometallic chemistry
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Parents

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Davit Zargarian research assistant 1994-1994 Université de Montréal
André B. Charette grad student 1996-2000 Université de Montréal
 (Premiere partie: Synthese enantioselective d'amines alpha-tertiaires. Deuxieme partie: Synthese d'halogenocyclopropylmethanols.)
Samuel J. Danishefsky post-doc 2001-2002 Columbia
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Publications

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Leroy M, Mélin L, LaPlante SR, et al. (2019) Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity. Bioorganic & Medicinal Chemistry Letters
Hébert M, Petiot P, Benoit E, et al. (2016) Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions. The Journal of Organic Chemistry
Taillemaud S, Diercxsens N, Gagnon A, et al. (2015) Mechanism-Driven Elaboration of an Enantioselective Bromocyclopropanation Reaction of Allylic Alcohols. Angewandte Chemie (International Ed. in English)
Beaulieu PL, Bolger G, Deon D, et al. (2015) Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity. Bioorganic & Medicinal Chemistry Letters. 25: 1140-5
Beaulieu PL, Bolger G, Duplessis M, et al. (2015) Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite. Bioorganic & Medicinal Chemistry Letters. 25: 1135-9
Petiot P, Dansereau J, Hébert M, et al. (2015) Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents. Organic & Biomolecular Chemistry. 13: 1322-7
Petiot P, Dansereau J, Hébert M, et al. (2015) Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents Organic and Biomolecular Chemistry. 13: 1322-1327
Gehling VS, Vaswani RG, Nasveschuk CG, et al. (2015) Discovery, design, and synthesis of indole-based EZH2 inhibitors Bioorganic and Medicinal Chemistry Letters. 25: 3644-3649
Nasveschuk CG, Gagnon A, Garapaty-Rao S, et al. (2014) Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2. Acs Medicinal Chemistry Letters. 5: 378-83
Crifar C, Petiot P, Ahmad T, et al. (2014) Synthesis of highly functionalized diaryl ethers by copper-mediated O-arylation of phenols using trivalent arylbismuth reagents Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 2755-2760
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