Alfred Goldberg

Affiliations: 
Harvard Medical School, Boston, MA, United States 
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"Alfred Goldberg"
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Parents

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Howard M. Goodman grad student
James D. Watson grad student

Children

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Judith Frydman grad student (Neurotree)
Ami Navon post-doc Harvard Medical School
Xiaobo Qiu post-doc Harvard Medical School (Neurotree)
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Publications

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Lee D, Goldberg AL. (2022) 26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122482119
Collins GA, Sha Z, Kuo CL, et al. (2022) Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation. The Journal of Biological Chemistry. 101875
Goldberg AL, Kim HT, Lee D, et al. (2021) Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation. Biomolecules. 11
VerPlank JJS, Tyrkalska SD, Fleming A, et al. (2020) cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 117: 14220-14230
Collins GA, Goldberg AL. (2020) Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation. Proceedings of the National Academy of Sciences of the United States of America
Sha Z, Blyszcz T, González-Prieto R, et al. (2019) Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. The Journal of Biological Chemistry
Jiang TX, Zou JB, Zhu QQ, et al. (2019) SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proceedings of the National Academy of Sciences of the United States of America
VerPlank JJS, Lokireddy S, Zhao J, et al. (2019) 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation. Proceedings of the National Academy of Sciences of the United States of America
Fraga H, Rodriguez B, Bardera A, et al. (2018) Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis. Analytical Biochemistry
Kim HT, Goldberg AL. (2018) UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells. Proceedings of the National Academy of Sciences of the United States of America
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