Tsan Sam Xiao

1995-2001 University of Texas Southwestern Medical Center, Dallas, TX, United States 
 2001-2006 Harvard Medical School, Boston, MA, United States 
 2006-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases 
 2014- Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Inflammasome, pyroptosis, innate immunity
"Tsan Xiao"
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Li Y, Liu Z, Zhao Y, et al. (2022) PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. Genes & Diseases. 10: 1702-1713
Xu Z, Deng S, Huang Y, et al. (2022) The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation. Frontiers in Immunology. 13: 1047922
Basavarajappa SC, Liu AR, Bruchez A, et al. (2022) Trimeric Receptor Binding Domain of SARS-CoV-2 Acts as a Potent Inhibitor of ACE2 Receptor-Mediated Viral Entry. Iscience. 104716
Zhang Q, Liu W, Wang H, et al. (2022) TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406
Liu Z, Xiao TS. (2021) Partners with a killer: Metabolic signaling promotes inflammatory cell death. Cell. 184: 4374-4376
Fan X, Jiang J, Zhao D, et al. (2021) Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Research
Liu Z, Wang C, Yang J, et al. (2020) Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity
Srinivasan S, Liu Z, Chuenchor W, et al. (2020) Function of Auxiliary Domains of the DEAH/RHA Helicase DHX36 in RNA Remodeling. Journal of Molecular Biology
Rathkey JK, Xiao TS, Abbott DW. (2020) Human polymorphisms in Gsdmd alter the inflammatory response. The Journal of Biological Chemistry
Liu Z, Wang C, Yang J, et al. (2019) Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity
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