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Tsan Sam Xiao

Affiliations: 
1995-2001 University of Texas Southwestern Medical Center, Dallas, TX, United States 
 2001-2006 Harvard Medical School, Boston, MA, United States 
 2006-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases 
 2014- Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Inflammasome, pyroptosis, innate immunity
Website:
https://case.edu/medicine/pathology/faculty/tsan-sam-xiao
Google:
"Tsan Xiao"
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Parents

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Stephen R. Sprang grad student 1995-2000 University of Texas Southwester Medical Center
Stephen R. Sprang post-doc 2000-2001 University of Texas Southwester Medical Center
Timothy A. Springer post-doc 2001-2006 Harvard Medical School
Jia-huai Wang post-doc 2001-2006 Harvard Medical School, Dana Farber Cancer Institute

Children

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Jie Yang grad student 2015-2019 Case Western Medical School
Rui Yang grad student 2017-2019 Case Western Medical School
Tinghe Wu post-doc 2007-2008 National Institutes of Health, National Institute of Allergy and Infectious Diseases
Ruiling Mu post-doc 2006-2011 National Institutes of Health, National Institute of Allergy and Infectious Diseases
Greg A. Snyder post-doc 2006-2011 National Institutes of Health, National Institute of Allergy and Infectious Diseases
Tengchuan Jin post-doc 2008-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases
Watchalee Chuenchor post-doc 2011-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases
Geoffrey E. Ravilious post-doc 2012-2014 National Institutes of Health, National Institute of Allergy and Infectious Diseases (Physics Tree)
Zhonghua Liu post-doc 2015-2020 Case Western Medical School

Collaborators

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Derek Abbott collaborator 2014- Case Western Medical School
George R. Dubyak collaborator 2014- Case Western Medical School (Physics Tree)
Eckhard Jankowsky collaborator 2014- Case Western Medical School
BETA: Related publications

Publications

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Liu Z, Li S, Wang C, et al. (2024) Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400883121
Busscher BM, Befekadu HB, Liu Z, et al. (2023) SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence. Viruses. 15
Li S, Bracey S, Liu Z, et al. (2023) Regulation of gasdermins in pyroptosis and cytokine release. Advances in Immunology. 158: 75-106
Li Y, Liu Z, Zhao Y, et al. (2022) PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain. Genes & Diseases. 10: 1702-1713
Xu Z, Deng S, Huang Y, et al. (2022) The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation. Frontiers in Immunology. 13: 1047922
Basavarajappa SC, Liu AR, Bruchez A, et al. (2022) Trimeric Receptor Binding Domain of SARS-CoV-2 Acts as a Potent Inhibitor of ACE2 Receptor-Mediated Viral Entry. Iscience. 104716
Zhang Q, Liu W, Wang H, et al. (2022) TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406
Liu Z, Xiao TS. (2021) Partners with a killer: Metabolic signaling promotes inflammatory cell death. Cell. 184: 4374-4376
Fan X, Jiang J, Zhao D, et al. (2021) Structural mechanism of DNA recognition by the p204 HIN domain. Nucleic Acids Research
Liu Z, Wang C, Yang J, et al. (2020) Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity
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