Derek Abbott
Affiliations: | Pathology | Case Western Reserve University School of Medicine, Cleveland, OH, United States |
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Collaborators
Sign in to add collaborator| Tsan Sam Xiao | collaborator | 2014- | Case Western Medical School |
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Publications
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| Zhou B, Abbott DW. (2023) Chemical modulation of gasdermin D activity: Therapeutic implications and consequences. Seminars in Immunology. 70: 101845 |
| Zhou B, Ryder CB, Dubyak GR, et al. (2022) Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies. Science Signaling. 15: eabl6781 |
| Zhang Q, Liu W, Wang H, et al. (2022) TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nature Communications. 13: 2406 |
| Liu Z, Wang C, Yang J, et al. (2020) Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity |
| Rathkey JK, Xiao TS, Abbott DW. (2020) Human polymorphisms in Gsdmd alter the inflammatory response. The Journal of Biological Chemistry |
| Liu Z, Wang C, Yang J, et al. (2019) Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization. Immunity |
| Zhang CJ, Jiang M, Zhou H, et al. (2018) TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. The Journal of Clinical Investigation |
| Rathkey JK, Zhao J, Liu Z, et al. (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Science Immunology. 3 |
| Chirieleison SM, Rathkey JK, Abbott DW. (2018) Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Science Signaling. 11 |
| Yang J, Liu Z, Wang C, et al. (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proceedings of the National Academy of Sciences of the United States of America |