Roland Edward Lehr

Chemistry and Biochemistry University of Oklahoma, Norman, OK, United States 
carcinogenesis by polycyclic aromatic hydrocarbons
"Roland Edward Lehr" OR "Roland E Lehr"

(1942 - 2003)

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Robert B. Woodward grad student 1969 Harvard
 (Orbital Symmetry Control of Cross-conjugated Dilenone Cyclizations: The Acid-catalyzed Cyclization of 3, 4-di-(4-oxo-cyclohexen-1-yl)-hexanediol-3, 4.)
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Chang RL, Wood AW, Kumar S, et al. (2000) Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice. Carcinogenesis. 21: 1997-2003
Adams JD, Sayer JM, Chadha A, et al. (1999) The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. Chemico-Biological Interactions. 122: 117-35
Ma S, Lin L, Raghavan R, et al. (1995) In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs. Journal of Medicinal Chemistry. 38: 4087-97
Lakshman MK, Chaturvedi S, Lehr RE. (1994) Improved high-yield synthesis of polycyclic aromatic hydrocarbon amino tribenzoates, nucleophilic components for synthesis of diol epoxide-nucleoside adducts Synthetic Communications. 24: 2983-2988
Lakshman MK, Lehr RE. (1994) Synthesis of 1,2-epoxy-1,2,3,4-tetrahydro-benzofe]chrysene: The first synthesis of a fjord-region tetrahydroepoxide Synthetic Communications. 24: 2973-2981
Lakshman MK, Lehr RE. (1992) Solvent dependent changes in the proton nmr spectra of 2’ -deoxyadenosine and its derivatives Nucleosides and Nucleotides. 11: 1039-1046
Lakshman M, Lehr RE. (1990) Synthesis of polycyclic aromatic hydrocarbon 2′-deoxyadenosine analogs Tetrahedron Letters. 31: 1547-1550
Wood AW, Chang RL, Levin W, et al. (1986) Bacterial and mammalian cell mutagenicity of four optically active bay-region 3,4-diol-1,2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine. Cancer Research. 46: 2760-6
Lehr RE, Kole PL, Tschappat KD. (1986) Acetoxylation at benzylic positions of tetrahydrobenzo rings with DDQ in acetic acid Tetrahedron Letters. 27: 1649-1652
Chang RL, Levin W, Wood AW, et al. (1984) Tumorigenicity of dihydrodiols and diol-epoxides of benz[c]acridine in newborn mice. Cancer Research. 44: 5161-4
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