Luke J. Dowman, PhD

Affiliations: 
2016-2021 Chemistry University of Sydney, Camperdown, New South Wales, Australia 
 2021- Flagship Venture Labs 
Area:
Organic Chemistry, Chemical Biology, Peptide and Protein Chemistry, Peptide Drug Discovery, Medicinal Chemistry
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"Luke Dowman"
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Dockerill M, Ford DJ, Angerani S, et al. (2024) Development of supramolecular anticoagulants with on-demand reversibility. Nature Biotechnology
Hanna CC, Kriegesmann J, Dowman LJ, et al. (2022) Chemische Synthese und Semisynthese von lipidierten Proteinen. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 134: e202111266
Dowman LJ, Kulkarni SS, Alegre-Requena JV, et al. (2022) Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Nature Communications. 13: 6885
Hanna C, Kriegesmann J, Dowman L, et al. (2021) Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angewandte Chemie (International Ed. in English)
Dowman LJ, Agten SM, Ripoll-Rozada J, et al. (2021) Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues. Chemical Communications (Cambridge, England)
Agten S, Watson E, Ripoll-Rozada J, et al. (2020) Potent trivalent inhibitors of thrombin through hybridization of salivary sulfopeptides from hematophagous arthropods. Angewandte Chemie (International Ed. in English)
Calisto BM, Ripoll-Rozada J, Dowman LJ, et al. (2020) Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates. Cell Chemical Biology
Wang X, Ashhurst AS, Dowman LJ, et al. (2020) Total Synthesis of Glycosylated Human Interferon-γ. Organic Letters
Clayton D, Kulkarni SS, Sayers J, et al. (2020) Chemical synthesis of a haemathrin sulfoprotein library reveals enhanced thrombin inhibition following tyrosine sulfation Rsc Chemical Biology. 1: 379-384
Chisholm TS, Clayton D, Dowman LJ, et al. (2018) Native Chemical Ligation-Photodesulfurization in Flow. Journal of the American Chemical Society
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