Bruce Fahr, PhD
Affiliations: | 1992-1997 | Chemistry and Biochemistry | University of California, Los Angeles, Los Angeles, CA |
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| Yang W, Fucini RV, Fahr BT, et al. (2009) Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. Biochemistry. 48: 4488-96 |
| Choong IC, Serafimova I, Fan J, et al. (2008) A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorganic & Medicinal Chemistry Letters. 18: 5763-5 |
| Fucini RV, Hanan EJ, Romanowski MJ, et al. (2008) Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5648-52 |
| Fahr BT, O'Brien T, Pham P, et al. (2006) Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorganic & Medicinal Chemistry Letters. 16: 559-62 |
| O'Brien T, Fahr BT, Sopko MM, et al. (2005) Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 451-8 |
| Wiesmann C, Barr KJ, Kung J, et al. (2004) Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology. 11: 730-7 |
| Allen DA, Pham P, Choong IC, et al. (2003) Identification of potent and novel small-molecule inhibitors of caspase-3. Bioorganic & Medicinal Chemistry Letters. 13: 3651-5 |
| Choong IC, Lew W, Lee D, et al. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. Journal of Medicinal Chemistry. 45: 5005-22 |