Li Tan, Ph.D
Affiliations: | 2000-2004 | Nanjing University, Nanjing Shi, Jiangsu Sheng, China | |
| 2004-2009 | SIOC,CAS | ||
| 2010-2016 | Harvard Medical School, Dana Farber Cancer Institute | ||
| 2016- | SIOC,CAS |
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Publications
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| Tao Y, Xia W, Zhao Q, et al. (2023) Structural mechanism for specific binding of chemical compounds to amyloid fibrils. Nature Chemical Biology |
| Chan S, Zhang Y, Wang J, et al. (2022) Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. Journal of Medicinal Chemistry |
| Tan L, Shan H, Han C, et al. (2022) Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. Journal of Medicinal Chemistry |
| Donovan KA, Ferguson FM, Bushman JW, et al. (2020) Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell |
| Schröder M, Tan L, Wang J, et al. (2020) Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chemical Biology |
| Pinch BJ, Doctor ZM, Nabet B, et al. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology |
| Zhang YH, Li YF, Wang Y, et al. (2020) Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nature Communications. 11: 1473 |
| Tan L, Zhang Z, Gao D, et al. (2019) Quinolone antibiotic derivatives as new selective Axl kinase inhibitors. European Journal of Medicinal Chemistry. 166: 318-327 |
| Pinch B, Doctor Z, Browne CM, et al. (2019) Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine Cancer Research. 79: 2757-2757 |
| Kozono S, Lin YM, Seo HS, et al. (2018) Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nature Communications. 9: 3069 |