Assia Shisheva
Affiliations: | Wayne State Univ Sch Med, Detroit, MI, United States |
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Ikonomov OC, Sbrissa D, Shisheva A. (2019) Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations. Toxicology and Applied Pharmacology. 114771 |
Shisheva A, Sbrissa D, Hu B, et al. (2019) Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J. Molecular Neurobiology |
Sbrissa D, Naisan G, Ikonomov OC, et al. (2018) Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. Plos One. 13: e0204532 |
Sbrissa D, Semaan L, Govindarajan B, et al. (2018) A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells. Oncogene |
Ikonomov OC, Altankov G, Sbrissa D, et al. (2018) PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and Applied Pharmacology. 356: 151-158 |
Tisdale EJ, Talati NK, Artalejo CR, et al. (2016) GAPDH binds Akt to facilitate cargo transport in the early secretory pathway. Experimental Cell Research. 349: 310-319 |
Compton LM, Ikonomov OC, Sbrissa D, et al. (2016) Active vacuolar H+ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. American Journal of Physiology. Cell Physiology. ajpcell.00104.2016 |
Ikonomov OC, Sbrissa D, Delvecchio K, et al. (2016) Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiological Reports. 4 |
Venkatareddy M, Verma R, Kalinowski A, et al. (2016) Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells. Journal of the American Society of Nephrology : Jasn |
Ikonomov OC, Sbrissa D, Compton LM, et al. (2015) The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation. The Journal of Biological Chemistry |