Assia Shisheva

Affiliations: 
Wayne State Univ Sch Med, Detroit, MI, United States 
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"Assia Shisheva"
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Ikonomov OC, Sbrissa D, Shisheva A. (2019) Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations. Toxicology and Applied Pharmacology. 114771
Shisheva A, Sbrissa D, Hu B, et al. (2019) Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J. Molecular Neurobiology
Sbrissa D, Naisan G, Ikonomov OC, et al. (2018) Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. Plos One. 13: e0204532
Sbrissa D, Semaan L, Govindarajan B, et al. (2018) A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells. Oncogene
Ikonomov OC, Altankov G, Sbrissa D, et al. (2018) PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and Applied Pharmacology. 356: 151-158
Tisdale EJ, Talati NK, Artalejo CR, et al. (2016) GAPDH binds Akt to facilitate cargo transport in the early secretory pathway. Experimental Cell Research. 349: 310-319
Compton LM, Ikonomov OC, Sbrissa D, et al. (2016) Active vacuolar H+ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. American Journal of Physiology. Cell Physiology. ajpcell.00104.2016
Ikonomov OC, Sbrissa D, Delvecchio K, et al. (2016) Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development. Physiological Reports. 4
Venkatareddy M, Verma R, Kalinowski A, et al. (2016) Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells. Journal of the American Society of Nephrology : Jasn
Ikonomov OC, Sbrissa D, Compton LM, et al. (2015) The protein complex of neurodegeneration-related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy-body-associated Synphilin-1 preventing its aggregation. The Journal of Biological Chemistry
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