Joanna Watt

Pharmacology University of Oxford, Oxford, United Kingdom 
"Joanna Watt"
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Su X, Dohle W, Mills SJ, et al. (2020) Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d--Inositol 1,4,5-Trisphosphate Receptors. Acs Omega. 5: 28793-28811
Baszczyňski O, Watt JM, Rozewitz MD, et al. (2020) Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR). Rsc Advances. 10: 1776-1785
Baszczyňski O, Watt JM, Rozewitz MD, et al. (2019) Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2. The Journal of Organic Chemistry. 84: 6143-6157
Kühn FJP, Watt JM, Potter BVL, et al. (2019) Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR. Scientific Reports. 9: 4985
Zhang B, Watt JM, Cordiglieri C, et al. (2018) Small Molecule Antagonists of NAADP-Induced Ca Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease. Scientific Reports. 8: 16775
Watt JM, Thomas MP, Potter BVL. (2018) Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers. Scientific Reports. 8: 15268
Watt JM, Graeff R, Thomas MP, et al. (2017) Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose". Scientific Reports. 7: 16100
Kyratsous NI, Bauer IJ, Zhang G, et al. (2017) Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America
Fliegert R, Bauche A, Wolf Pérez AM, et al. (2017) 2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nature Chemical Biology
Fliegert R, Watt JM, Schöbel A, et al. (2017) Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349. The Biochemical Journal
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