Xin-Shan Ye, Ph.D.
|2000-||School of Pharmaceutical science||Peking University Health Science Center, China|
Area:Organic Chemistry; Medicinal Chemistry; Chemical Glycobiology
• B.Sc. Wuhan University, 1981-1985
• M. Sc. Wuhan University, 1985-1988 (supervised by Prof. Cheng-Tai Wu, Synthesis of crown ether compounds)
• Ph.D. The Chinese University of Hong Kong, 1993-1996 (supervised by Prof. Henry N. C. Wong, Synthesis of 3,4-disubstituted thiophenes)
• Lecturer Huazhong Agricultural University, 1988-1993
• Research Associate The Scripps Research Institute, USA, 1996-2000 (under the direction of Prof. Chi-Huey Wong, Synthesis of oligosaccharide library)
• Professor Peking University, 2000-
QUALIFICATIONS AND AWARDS
• Cheung Kong Scholars Programme Professionship (2000)
• National Outstanding Young Investigator Award by Natural Science Foundation of China (2005)
• Director of the State Key Laboratory of Natural and Biomimetic Drugs (2005-present)
• Natural Science Award of Ministry of Education, China, Second Class (2010)
• WuXi PharmaTech Life Science and Chemistry Award, Second Class (2010)
• Science and Technology Award of Chinese Pharmaceutical Association, First Class (2011)
• Development of new methodologies or strategies for the assembly of oligosaccharides.
• Synthesis and evaluation of biologically important oligosaccharides such as tumor-associated antigens.
• Design, synthesis and evaluation of carbohydrate-processing enzyme inhibitors as well as discovery of new carbohydrate-based drugs.
• Chemical modifications of aminoglycoside antibiotics.
JOURNAL EDITING ACTIVITIES
• Co-Editors-in-Chief of Current Topics in Medicinal Chemistry (2014-)
• Member of International Advisory Board of ChemMedChem (2014-)
• Member of Editorial Board of Carbohydrate Research (2009-)
• Member of Editorial Board of Chinese Journal of Organic Chemistry (2007-)
• Member of Editorial Board of Chemical Journal of Chinese Universities (2007-)
• Member of Editorial Board of Chinese Journal of Medicinal Chemistry (2006-)
• Member of Editorial Board of Chinese Journal of New Drugs (2009-)
• Member of Editorial Board of Acta Scientiarum Naturalium Universitatis Pekinensis (2005-)
• Associate Editor-in-Chief of Journal of Chinese Pharmaceutical Sciences (2005-)
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|Chen YF, Zhu JJ, Li J, et al. (2021) O-GlcNAcylation increases PYGL activity by promoting phosphorylation. Glycobiology|
|Chen YF, Shao GC, Li J, et al. (2021) O-GlcNAcylation of Blimp-1 in lymphocytes inhibits its transcriptional function and is associated with migration and invasion of breast cancer cells. Molecular Cancer Research : McR|
|Deng L, Song C, Niu Y, et al. (2021) Synthesis and biological evaluation of bergenin derivatives as new immunosuppressants. Rsc Medicinal Chemistry. 12: 1968-1976|
|Cao Y, Zhou M, Mao RZ, et al. (2021) Visible-light-promoted 3,5-dimethoxyphenyl glycoside activation and glycosylation. Chemical Communications (Cambridge, England). 57: 10899-10902|
|Li G, Ma W, Mo J, et al. (2021) Influenza Virus Precision Diagnosis and Continuous Purification Enabled by Neuraminidase-Resistant Glycopolymer-Coated Microbeads. Acs Applied Materials & Interfaces|
|Liu M, Qin X, Ye XS. (2021) Glycan Assembly Strategy: From Concept to Application. Chemical Record (New York, N.Y.)|
|Liu M, Luo ZX, Li T, et al. (2021) Electrochemical Trifluoromethylation of Glycals. The Journal of Organic Chemistry|
|Zhai C, Zheng XJ, Song C, et al. (2021) Synthesis and immunological evaluation of -acyl modified Globo H derivatives as anticancer vaccine candidates. Rsc Medicinal Chemistry. 12: 1239-1243|
|Wu X, Wu Y, Zheng R, et al. (2021) Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. Embo Reports. e51678|
|Zhang ZP, Xue WY, Hu JX, et al. (2020) Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors. Chinese Journal of Natural Medicines. 18: 729-737|