James John Crawford

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
Area:
Medicinal Chemistry; Organic Chemistry; Drug Discovery
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"James Crawford"
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Publications

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Hunter JH, Anderson MJ, Castan IFSF, et al. (2021) Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries. Chemical Science. 12: 9475-9484
Crawford JJ, Lee W, Johnson AR, et al. (2020) Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity. Acs Medicinal Chemistry Letters. 11: 1588-1597
Zhang C, Crawford JJ, Landry ML, et al. (2020) Strategies to Mitigate the Bioactivation of Aryl Amines. Chemical Research in Toxicology
Crawford JJ, Liao D, Kolesnikov A, et al. (2020) Synthesis of an Azabicyclo[3.1.0]hexanone-Containing Inhibitor of NF-κΒ Inducing Kinase via Catalytic C–H Activation Synthesis
Bronner SM, Merrick KA, Murray J, et al. (2019) Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorganic & Medicinal Chemistry Letters
Crawford JJ, Bronner SM, Zbieg JR. (2018) Hippo pathway inhibition by blocking the YAP/TAZ-TEAD interface: a patent review. Expert Opinion On Therapeutic Patents
Blaquiere N, Castanedo G, Burch J, et al. (2018) A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry
Crawford JJ, Johnson AR, Misner DL, et al. (2018) Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development. Journal of Medicinal Chemistry
Wang X, Barbosa J, Blomgren P, et al. (2017) Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. Acs Medicinal Chemistry Letters. 8: 608-613
Castanedo G, Liu Y, Crawford JJ, et al. (2016) Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)-H bonds. The Journal of Organic Chemistry
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