Richard Lee

Affiliations: 
Chemical Biology & Therapeutics St. Jude Children's Research Hospital, San Francisco, CA, United States 
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Miao Y, Yadav V, Shadrick W, et al. (2025) Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways. Biorxiv : the Preprint Server For Biology
Scott DC, Dharuman S, Griffith E, et al. (2024) Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nature Communications. 15: 8829
Marreddy RKR, Phelps GA, Churion K, et al. (2024) Chemical genetic analysis of enoxolone inhibition of C. difficile toxin production reveals adenine deaminase and ATP synthase as anti-virulence targets. The Journal of Biological Chemistry. 107839
Lewis K, Lee RE, Brötz-Oesterhelt H, et al. (2024) Sophisticated natural products as antibiotics. Nature. 632: 39-49
Dharuman S, Phelps GA, Dunn CM, et al. (2024) Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins. The Journal of Antibiotics
Phelps GA, Cheramie MN, Fernando DM, et al. (2024) Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in abscessus. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314101120
Buchholz CR, Sneddon MS, McPherson JE, et al. (2023) Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors. Acs Medicinal Chemistry Letters. 14: 1441-1447
Scott DC, King MT, Baek K, et al. (2023) E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Molecular Cell
Leshchiner D, Rosconi F, Sundaresh B, et al. (2022) A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance. Nature Communications. 13: 3165
Dharuman S, Wallace MJ, Reeve SM, et al. (2022) Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against . Molecules (Basel, Switzerland). 27
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