Marianne Grunberg-Manago

Biochemistry Institut de Biologie Physico-Chimique 
polynucleotide phosphorylase (PNPase)
"Marianne Grunberg-Manago"

(1921 - 2013)
Discoverer with Severo Ochoa of polynucleotide phosphorylase (PNPase), an enzyme that became an essential tool for deciphering the genetic code. For this discovery Ochoa received the Nobel Prize in Medicine in 1959.

Mean distance: 9.19


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Severo Ochoa post-doc 1954 NYU


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Michael Laughrea research scientist 1978 (Cell Biology Tree)
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Bénard L, Mathy N, Grunberg-Manago M, et al. (1998) Identification in a pseudoknot of a U.G motif essential for the regulation of the expression of ribosomal protein S15. Proceedings of the National Academy of Sciences of the United States of America. 95: 2564-7
Mirzabekov AD, Bernardi G, Cohen SN, et al. (1995) In memoriam Alexander A. Bayev, 1904-1994. Gene. 162: 1-3
Gagnon Y, Breton R, Putzer H, et al. (1994) Clustering and co-transcription of the Bacillus subtilis genes encoding the aminoacyl-tRNA synthetases specific for glutamate and for cysteine and the first enzyme for cysteine biosynthesis. The Journal of Biological Chemistry. 269: 7473-82
Shazand K, Tucker J, Grunberg-Manago M, et al. (1993) Similar organization of the nusA-infB operon in Bacillus subtilis and Escherichia coli. Journal of Bacteriology. 175: 2880-7
Sacerdot C, Vachon G, Laalami S, et al. (1992) Both forms of translational initiation factor IF2 (alpha and beta) are required for maximal growth of Escherichia coli. Evidence for two translational initiation codons for IF2 beta. Journal of Molecular Biology. 225: 67-80
Laalami S, Sacerdot C, Vachon G, et al. (1991) Structural and functional domains of E coli initiation factor IF2. Biochimie. 73: 1557-66
Portier C, Dondon L, Grunberg-Manago M. (1990) Translational autocontrol of the Escherichia coli ribosomal protein S15. Journal of Molecular Biology. 211: 407-14
Vachon G, Laalami S, Grunberg-Manago M, et al. (1990) Purified internal G-domain of translational initiation factor IF-2 displays guanine nucleotide binding properties. Biochemistry. 29: 9728-33
Shazand K, Tucker J, Chiang R, et al. (1990) Isolation and molecular genetic characterization of the Bacillus subtilis gene (infB) encoding protein synthesis initiation factor 2. Journal of Bacteriology. 172: 2675-87
Morel-Deville F, Vachon G, Sacerdot C, et al. (1990) Characterization of the translational start site for IF2 beta, a short form of Escherichia coli initiation factor IF2. European Journal of Biochemistry / Febs. 188: 605-14
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