Marianne Grunberg-Manago

Biochemistry Institut de Biologie Physico-Chimique 
polynucleotide phosphorylase (PNPase)
"Marianne Grunberg-Manago"

(1921 - 2013)
Discoverer with Severo Ochoa of polynucleotide phosphorylase (PNPase), an enzyme that became an essential tool for deciphering the genetic code. For this discovery Ochoa received the Nobel Prize in Medicine in 1959.

Mean distance: 9.19


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Severo Ochoa post-doc 1954 NYU


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Michael Laughrea research scientist 1978 (Cell Biology Tree)
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Portier C, Dondon L, Grunberg-Manago M. (1990) Translational autocontrol of the Escherichia coli ribosomal protein S15. Journal of Molecular Biology. 211: 407-14
Moine H, Romby P, Springer M, et al. (1990) Escherichia coli threonyl-tRNA synthetase and tRNA(Thr) modulate the binding of the ribosome to the translational initiation site of the thrS mRNA. Journal of Molecular Biology. 216: 299-310
Moine H, Ehresmann B, Romby P, et al. (1990) The translational regulation of threonyl-tRNA synthetase. Functional relationship between the enzyme, the cognate tRNA and the ribosome. Biochimica Et Biophysica Acta. 1050: 343-50
Grunberg-Manago M, Ortiz PJ, Ochoa S. (1989) Enzymic synthesis of polynucleotides. I. Polynucleotide phosphorylase of Azotobacter vinelandii. 1956. Biochimica Et Biophysica Acta. 1000: 65-81
Ehresmann B, Moine H, Romby P, et al. (1988) Secondary structure of the Escherichia coli translational operator of threonyl-tRNA synthetase and relationship to its function. Gene. 72: 187-8
Springer M, Graffe M, Dondon J, et al. (1988) Translational control in E. coli: the case of threonyl-tRNA synthetase. Bioscience Reports. 8: 619-32
Theobald A, Springer M, Grunberg-Manago M, et al. (1988) Tertiary structure of Escherichia coli tRNA(3Thr) in solution and interaction of this tRNA with the cognate threonyl-tRNA synthetase. European Journal of Biochemistry / Febs. 175: 511-24
Sands JF, Cummings HS, Sacerdot C, et al. (1987) Cloning and mapping of infA, the gene for protein synthesis initiation factor IF1. Nucleic Acids Research. 15: 5157-68
Cenatiempo Y, Deville F, Dondon J, et al. (1987) The protein synthesis initiation factor 2 G-domain. Study of a functionally active C-terminal 65-kilodalton fragment of IF2 from Escherichia coli. Biochemistry. 26: 5070-6
Trudel M, Springer M, Graffe M, et al. (1984) Regulation of E.coli phenylalanyl-tRNA synthetase operon in vivo. Biochimica Et Biophysica Acta. 782: 10-7
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