John Cavanagh, Ph.D.

Affiliations: 
Structural & Molecular Biochemistry North Carolina State University, Raleigh, NC 
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Benjamin G. Bobay grad student 2004 NCSU
Douglas J. Kojetin grad student 2000-2005 NCSU
David R. Kordys grad student 2007 NCSU
Patrick D. McLaughlin grad student 2007 NCSU
Daniel M. Sullivan grad student 2008 NCSU
Carey A. Hobbs grad student 2009 NCSU
Sean D. Stowe grad student 2013 NCSU
Ashley T. Tucker grad student 2013 NCSU
C. Leigh Allen post-doc 2014-2016 NCSU
Morgan E. Milton post-doc 2016-2022 Brody School of Medicine East Carolina University
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Publications

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Milton ME, Cavanagh J. (2022) The Biofilm Regulatory Network from Bacillus subtilis: A Structure-Function Analysis. Journal of Molecular Biology. 435: 167923
Zeczycki TN, Milton ME, Jung D, et al. (2022) 2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria. Biochemistry
Palethorpe S, Farrow JM, Wells G, et al. (2021) regulates its stress responses via the BfmRS two-component regulatory system. Journal of Bacteriology. JB0049421
Palethorpe S, Milton ME, Pesci EC, et al. (2021) Structure of the Acinetobacter baumannii PmrA receiver domain and insights into clinical mutants affecting DNA-binding and promoting colistin resistance. Journal of Biochemistry
Dean SN, Milton ME, Cavanagh J, et al. (2020) Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production. Frontiers in Cellular and Infection Microbiology. 10: 82
Milton ME, Draughn GL, Bobay BG, et al. (2019) The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. Journal of Molecular Biology
Milton ME, Minrovic BM, Harris DL, et al. (2018) Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR fromand QseB fromspp. Frontiers in Molecular Biosciences. 5: 15
Logan Draughn G, Milton ME, Feldmann EA, et al. (2018) The structure of the biofilm-controlling response regulator BfmR from Acinetobacter baumannii reveals details of its DNA-binding mechanism. Journal of Molecular Biology
Milton ME, Minrovic BM, Harris DL, et al. (2018) Resensitizing multidrug resistant bacteria to antibiotics by targeting bacterial response regulators. F1000research. 7
Milton ME, Leigh Allen C, Feldmann EA, et al. (2017) Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Molecular Microbiology
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