Daniel Santi
Affiliations: | Pharmacy | University of California, San Francisco, San Francisco, CA |
Area:
Medicinal ChemistryWebsite:
https://profiles.ucsf.edu/daniel.santiGoogle:
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Parents
Sign in to add mentor| Bernard Randall Baker | grad student | 1967 | SUNY Buffalo | |
| (Synthesis of some candidate pyrimidyl inhibitors of dihydrofolic reductase and thymidylate synthetase.) | ||||
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Publications
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| Stout TJ, Tondi D, Rinaldi M, et al. (1999) Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 38: 1607-17 |
| Costi M, Tondi D, Rinaldi M, et al. (1996) Naphthalimido derivatives as antifolate thymidylate synthase inhibitors European Journal of Medicinal Chemistry. 31: 1011-1016 |
| Gamarro F, Yu P, Zhao J, et al. (1995) Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme. Molecular and Biochemical Parasitology. 72: 11-22 |
| Eckstein JW, Foster PG, Finer-Moore J, et al. (1994) Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate. Biochemistry. 33: 15086-94 |
| Santi DV, Edman U, Minkin S, et al. (1992) Purification and characterization of recombinant Pneumocystis carinii thymidylate synthase. Protein Expression and Purification. 2: 350-4 |
| Carreras CW, Climie SC, Santi DV. (1992) Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation. Biochemistry. 31: 6038-44 |
| Sirawaraporn W, Edman JC, Santi DV. (1991) Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase Protein Expression and Purification. 2: 313-316 |
| Subramaniam R, Wang Y, Mathews CK, et al. (1989) On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2'-deoxycytidine 5'-monophosphate. Archives of Biochemistry and Biophysics. 275: 11-5 |
| Santi DV, Hardy LW. (1988) Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis. Biochemistry. 26: 8599-606 |
| Anderson RT, Santi DV. (1977) Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli B. Potent inhibition by analogues of N-benzyl-2-phenylethylamine. Journal of Medicinal Chemistry. 19: 1270-5 |