Joseph S. Vyle, PhD

Affiliations: 
1999- Chemistry and Chemical engineering Queen's University Belfast, Belfast, Northern Ireland, United Kingdom 
Area:
DNA, RNA nucleosides, nucleotides, sulfur, selenium, gel
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"Joseph Vyle"
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Parents

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Richard cosstick grad student 1986-1989
Marvin H. Caruthers post-doc 1989-1990
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Publications

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Conlon PF, Eguaogie O, Wilson JJ, et al. (2019) Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography. Chemical Science. 10: 10948-10957
Eguaogie O, Vyle JS, Conlon PF, et al. (2018) Mechanochemistry of nucleosides, nucleotides and related materials. Beilstein Journal of Organic Chemistry. 14: 955-970
Eguaogie O, Vyle JS. (2017) Vibration Ball Milling for the Synthesis of 5'-Thioadenosine 5'-Pyrophosphate (P'→5') Adenosine (dASppA). Current Protocols in Nucleic Acid Chemistry. 70: 1.41.1-1.41.12
Eguaogie O, Conlon PF, Ravalico F, et al. (2017) Nucleophilic displacement reactions of 5'-derivatised nucleosides in a vibration ball mill. Beilstein Journal of Organic Chemistry. 13: 87-92
Eguaogie O, Conlon PF, Vyle JS. (2016) Synthesis of nucleoside phosphoroselenolates via the efficient Michaelis-Arbuzov reaction of selenocyanates Tetrahedron Letters. 57: 5000-5002
Eguaogie O, Cooke LA, Martin PM, et al. (2015) Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill. Organic & Biomolecular Chemistry
Cummings AJ, Ravalico F, McColgan-Bannon KI, et al. (2015) Nucleoside azide-alkyne cycloaddition reactions under solvothermal conditions or using copper vials in a ball mill. Nucleosides, Nucleotides & Nucleic Acids. 34: 361-70
Freeman C, Vyle JS, Heaney F. (2013) Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry Rsc Advances. 3: 1652-1655
Singh I, Freeman C, Madder A, et al. (2012) Fast RNA conjugations on solid phase by strain-promoted cycloadditions. Organic & Biomolecular Chemistry. 10: 6633-9
Ravalico F, Messina I, Berberian MV, et al. (2011) Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill. Organic & Biomolecular Chemistry. 9: 6496-7
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