Geoffrey A. Preidis

Baylor College of Medicine, Houston, TX 
Liver and gastrointestinal physiology; gut microbiome

Geoffrey A. Preidis, M.D., Ph.D. is a board-certified Pediatric Gastroenterologist with basic research expertise in nutrition-sensitive mechanisms that regulate physiology, growth, and development. These include liver and intestinal gene regulation, enteric nervous system biology and gastrointestinal motility, bile acid homeostasis, and interactions between diet and the gut microbiome. He is actively involved in clinical and translational investigations of neonates and children with intestinal, liver, and nutritional disorders. His biomedical research career began during his undergraduate studies at Harvard University. He developed an interest in Pediatric Gastroenterology during his years in the Medical Scientist Training Program (M.D./Ph.D.) at Baylor College of Medicine. He completed internship and residency training in Pediatrics, as well as fellowship training in Pediatric Gastroenterology, Hepatology & Nutrition, at Baylor College of Medicine.

The goal of Dr. Preidis’s laboratory is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition impairs intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. This work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and psychosocial factors, including preterm and underweight newborns in the neonatal intensive care unit, adolescents with anorexia nervosa, and children with severe acute malnutrition in the developing world.
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Preidis GA, Soni KG, Suh JH, et al. (2020) Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatology Communications. 4: 1835-1850
Edwards PT, Kashyap PC, Preidis GA. (2020) Microbiota on Biotics: Probiotics, Prebiotics, and Synbiotics to Optimize Growth and Metabolism. American Journal of Physiology. Gastrointestinal and Liver Physiology
Thaxton GE, Melby PC, Manary MJ, et al. (2018) New Insights into the Pathogenesis and Treatment of Malnutrition. Gastroenterology Clinics of North America. 47: 813-827
Shin A, Preidis GA, Shulman R, et al. (2018) The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Preidis GA, Kim KH, Moore DD. (2017) Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. The Journal of Clinical Investigation
Velly H, Britton RA, Preidis GA. (2016) Mechanisms of Cross-talk between the Diet, the Intestinal Microbiome, and the Undernourished Host. Gut Microbes. 0
Preidis GA, Luna RA, Hollister EB, et al. (2016) The mucosal microbiota in a young child with severe non-Helicobacter gastritis. Therapeutic Advances in Gastroenterology. 9: 749-51
Preidis GA, Ajami NJ, Wong MC, et al. (2016) Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. The Journal of Nutrition
Preidis GA, Ajami NJ, Wong MC, et al. (2015) Composition and function of the undernourished neonatal mouse intestinal microbiome. The Journal of Nutritional Biochemistry
Preidis GA, Hotez PJ. (2015) The newest "omics"--metagenomics and metabolomics--enter the battle against the neglected tropical diseases. Plos Neglected Tropical Diseases. 9: e0003382
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