Timothy L. Macdonald

Chemistry University of Virginia, Charlottesville, VA 
Bioorganic and Synthetic Organic Chemistry
"Timothy L. Macdonald"


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Gilbert Stork grad student 1975 Columbia
 (Part I. Approaches to medium and large carbocycles via thru-carbon ring homologation : a synthesis of [plus or minus]-muscone. Part II. Studies on the transformation of corynanthe alkaloids into yohimbe and rauwolfia alkaloids)
William Summer Johnson post-doc 1977 Stanford


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Jetze J. Tepe grad student University of Virgina (Philosophy Tree)
José S. Madalengoitia grad student 1993 UVA
Lisa Landino grad student 1989-1994 UVA
Dara Edwards Keller grad student 2000 UVA
Prakash Ramaseshan Vachaspati grad student 2000 UVA
Ying Zou grad student 2000 UVA
Christine Marie Dieckhaus grad student 2001 UVA
Tiffany Nicole Heady grad student 2001 UVA
Amy Morin Deveau grad student 2002 UVA
Michael A. Johnson grad student 2002 UVA
Webster L. Santos grad student 2002 UVA
Kirsten S Smith grad student 1997-2002 UVA
Jayson Michael Rieger grad student 2003 UVA
Shane G. Roller grad student 2003 UVA
Jeremy J. Clemens grad student 2004 UVA
Elizabeth M. Joshi grad student 2004 UVA
Brian H. Heasley grad student 2005 UVA
Frank Wells Foss grad student 2006 UVA
Molly Z. Karlinsey grad student 2006 UVA
William F. McCalmont grad student 2006 UVA
Peng Cui grad student 2007 UVA
Fengping Li grad student 2008 UVA
Qin Sun grad student 2008 UVA
Ran Zhu grad student 2008 UVA
Thomas P. Mathews grad student 2010 UVA
James E. East grad student 2011 UVA
Min Yang grad student 2011 UVA
Andrew J Kennedy grad student 2007-2011 UVA
Tao Huang grad student 2012 UVA
Joseph D. Houck grad student 2013 UVA
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Houck JD, Dawson TK, Kennedy AJ, et al. (2016) Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92
Kennedy AJ, Bruce AM, Gineste C, et al. (2016) Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate: Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilon Proteobacteria. Antimicrobial Agents and Chemotherapy
Hoffman PS, Bruce AM, Olekhnovich I, et al. (2014) Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 58: 4703-12
Gray LS, Schiff D, Macdonald TL. (2013) A model for the regulation of T-type Ca2+ channels in proliferation: Roles in stem cells and cancer Expert Review of Anticancer Therapy. 13: 589-595
Peyruchaud O, David M, Macdonald TL, et al. (2013) Lysophosphatidic Acid (LPA) Signaling and Bone Cancer Lysophospholipid Receptors: Signaling and Biochemistry. 627-640
East JE, Macdonald TL. (2012) Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid. Synthetic Communications. 42: 3614-3618
Warren CA, van Opstal E, Ballard TE, et al. (2012) Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrobial Agents and Chemotherapy. 56: 4103-11
East JE, MacDonald TL. (2012) Cost-effective and large-scale synthesis of 16:0 lysophosphatidic acid Synthetic Communications. 42: 3614-3619
East JE, Carter KM, Kennedy PC, et al. (2011) Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330
Kharel Y, Mathews TP, Gellett AM, et al. (2011) Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53
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