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Lan Guan, MD, PhD

Affiliations: 
2008- Cell Physiology and Molecular Biophysics Texas Tech University Health Sciences Center 
Area:
membrane transport and structure biology
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"Lan Guan"
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Parents

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Taiji Nakae grad student 1997-2000 Tokai University School of Medicine
H. Ronald Kaback post-doc 2000-2008 UCLA

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Publications

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Hariharan P, Shi Y, Katsube S, et al. (2024) Mobile barrier mechanisms for Na-coupled symport in an MFS sugar transporter. Elife. 12
Yoon S, Bae HE, Hariharan P, et al. (2024) Rational Approach to Improve Detergent Efficacy for Membrane Protein Stabilization. Bioconjugate Chemistry
Ghani L, Kim S, Ehsan M, et al. (2023) Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance. Chemical Science. 14: 13014-13024
Hariharan P, Shi Y, Katsube S, et al. (2023) Mimicking the regulatory state of a major facilitator superfamily sugar transporter. Biorxiv : the Preprint Server For Biology
Blaimschein N, Parameswaran H, Nagler G, et al. (2023) The insertase YidC chaperones the polytopic membrane protein MelB inserting and folding simultaneously from both termini. Structure (London, England : 1993). 31: 1419-1430.e5
Katsube S, Willibal K, Vemulapally S, et al. (2023) In vivo and in vitro characterizations of melibiose permease (MelB) conformation- dependent nanobodies reveal sugar-binding mechanisms. The Journal of Biological Chemistry. 104967
Ghani L, Zhang X, Munk CF, et al. (2023) Tris(hydroxymethyl)aminomethane Linker-Bearing Triazine-Based Triglucosides for Solubilization and Stabilization of Membrane Proteins. Bioconjugate Chemistry
Chua GL, Tan BC, Loke RYJ, et al. (2023) Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215290120
Lee HS, Das M, Mahler F, et al. (2022) 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based maltosides (HDMs) for membrane-protein study: Importance of detergent rigidity-flexibility balance in protein stability. Chemistry, An Asian Journal
Guan L. (2022) Structure and mechanism of membrane transporters. Scientific Reports. 12: 13248
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