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Joseph Scott Brown

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
drug discovery, sequence-defined oligomers, peptides, molecular engineering, chemical biology
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"Joseph Brown"
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Parents

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Orlin D. Velev research assistant 2010-2013 NCSU
Christopher A. Alabi grad student 2013-2019 Cornell
Brad L. Pentelute post-doc 2019- MIT

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Publications

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Saebi A, Brown JS, Marando VM, et al. (2023) Rapid Single-Shot Synthesis of the 214 Amino Acid-Long N-Terminal Domain of Pyocin S2. Acs Chemical Biology
Zhang G, Brown JS, Quartararo AJ, et al. (2022) Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2. Communications Chemistry. 5: 8
Gazvoda M, Dhanjee HH, Rodriguez J, et al. (2022) Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins. Journal of the American Chemical Society
Pomplun S, Jbara M, Quartararo AJ, et al. (2021) Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein. Acs Central Science. 7: 156-163
Brown JS, Ruttinger AW, Vaidya AJ, et al. (2020) Decomplexation as a rate limitation in the thiol-Michael addition of N-acrylamides. Organic & Biomolecular Chemistry
Artim CM, Brown JS, Alabi CA. (2019) Biophysical Characterization of Cationic Antibacterial Oligothioetheramides. Analytical Chemistry
Brown JS, Mohamed ZJ, Artim CM, et al. (2018) Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency. Communications Biology. 1: 220
Brown JS, Mohamed ZJ, Artim CM, et al. (2018) Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency. Communications Biology. 1: 220
Hoff EA, Artim CM, Brown JS, et al. (2018) Sensitivity of Antibacterial Activity to Backbone Sequence in Constitutionally Isomeric OligoTEAs. Macromolecular Bioscience. e1800241
Brown JS, Acevedo YM, He GD, et al. (2017) Synthesis and Solution-Phase Characterization of Sulfonated Oligothioetheramides. Macromolecules. 50: 8731-8738
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