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Fábio Cohen Tucci, Ph.D.

Affiliations: 
2010- Epigen Biosciences 
Area:
Industrial Chemistry, Medicinal Chemistry, Pharmaceuticals
Website:
www.epigenbiosciences.com
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"Fábio Tucci"
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SNBCP

Parents

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Joseph P. Marino grad student 1992-1993 Notre Dame
 (F. C. Tucci was co-supervised by J. P. Marino on macrolactin A synthesis project in University of Michigan (Ann Arbor).)
João V. Comasseto grad student 1990-1994 USP
Julius Rebek, Jr. post-doc 1998-1999 The Scripps Research Institute, California, USA
Dmitry M. Rudkevich post-doc 1998-1999 The Scripps Research Institute, California, USA
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Publications

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Gaidhani N, Tucci FC, Kem WR, et al. (2021) Therapeutic efficacy of α7 ligands after acute ischemic stroke is linked to conductive states of α7 nAChRs. British Journal of Pharmacology
Woller SA, Ravula SB, Tucci FC, et al. (2016) Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain, Behavior, and Immunity
Ravula SB, Yu J, Tran JA, et al. (2012) Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia. Bioorganic & Medicinal Chemistry Letters. 22: 421-6
Huang C, Moree WJ, Zamani-Kord S, et al. (2011) Influence of pKa on the biotransformation of indene H 1-antihistamines by CYP2D6 Bioorganic and Medicinal Chemistry Letters. 21: 947-951
Moree WJ, Li BF, Zamani-Kord S, et al. (2010) Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia Bioorganic and Medicinal Chemistry Letters. 20: 5874-5878
Moree WJ, Jovic F, Coon T, et al. (2010) Novel benzothiophene H1-antihistamines for the treatment of insomnia Bioorganic and Medicinal Chemistry Letters. 20: 2316-2320
Moree WJ, Li BF, Jovic F, et al. (2009) Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. Journal of Medicinal Chemistry. 52: 5307-10
Chen C, Wu D, Guo Z, et al. (2008) Discovery of sodium R-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6- [trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl] -1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor Journal of Medicinal Chemistry. 51: 7478-7485
Marinkovic D, Tucci FC, Tran JA, et al. (2008) Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands Bioorganic and Medicinal Chemistry Letters. 18: 4817-4822
Chen C, Chen Y, Pontillo J, et al. (2008) Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity Bioorganic and Medicinal Chemistry Letters. 18: 3301-3305
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