Alexander L Nielsen

Affiliations: 
University of Copenhagen, København, Denmark 
Area:
Medicinal Chemistry
Google:
"Alexander L Nielsen"
Mean distance: (not calculated yet)
 

Parents

Sign in to add mentor
Kim David Janda grad student 2020-2020 Scripps Institute
 (Visiting Graduate Student)
Christian A. Olsen grad student 2017-2021 Copenhagen University
BETA: Related publications

Publications

You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect.

Rajabi N, Hansen TN, Nielsen AL, et al. (2022) Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme. Angewandte Chemie (International Ed. in English). e202115805
Moreno-Yruela C, Zhang D, Wei W, et al. (2022) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Science Advances. 8: eabi6696
Troelsen KS, Bæk M, Nielsen AL, et al. (2021) Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase. Rsc Chemical Biology. 2: 627-635
Nielsen AL, Rajabi N, Kudo N, et al. (2021) Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chemical Biology. 2: 612-626
Turner LD, Nielsen AL, Lin L, et al. (2021) Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Medicinal Chemistry Letters. 12: 1318-1324
Turner LD, Nielsen AL, Lin L, et al. (2021) Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach. Rsc Medicinal Chemistry. 12: 960-969
Shirey RJ, Hart JR, Sridharan B, et al. (2021) Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. Bioorganic & Medicinal Chemistry. 42: 116246
Turner LD, Nielsen AL, Lin L, et al. (2021) COVALENT INHIBITION OF BOTULINUM NEUROTOXIN A - EXPLORATION OF WARHEAD REACTIVITY AND FUNCTION USING A BIFUNCTIONAL APPROACH. Toxicon : Official Journal of the International Society On Toxinology. 190: S72-S73
Nielsen AL, Rajabi N, Kudo N, et al. (2021) Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration Rsc Chemical Biology. 2: 612-626
Rajabi N, Nielsen AL, Olsen CA. (2020) Dethioacylation by Sirtuins 1-3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition. Acs Medicinal Chemistry Letters. 11: 1886-1892
See more...