Louis J. Ignarro

Molecular and Medical Pharmacology University of California, Los Angeles, Los Angeles, CA 
regulation and modulation of nitric oxide (NO) production and cytotoxicity in macrophages, vascular cells, and tumor cells
"Louis J. Ignarro"

The Nobel Prize in Physiology or Medicine 1998 was awarded jointly to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system.

Mean distance: 13.9


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Frederick E. Shideman grad student 1966 UMN
 (Catecholamines and the Enzymes Involved in Their Synthesis and Metabolism in the Embryonic and Developing Chick)
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He Y, Haque MM, Stuehr DJ, et al. (2015) Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics. Proceedings of the National Academy of Sciences of the United States of America
Karlsson JOG, Ignarro LJ, Lundström I, et al. (2015) Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties Drug Discovery Today. 20: 411-421
Meldrum DR, Burnett AL, Dorey G, et al. (2014) Erectile hydraulics: Maximizing inflow while minimizing outflow Journal of Sexual Medicine. 11: 1208-1220
Hayashi T, Kotani H, Yamaguchi T, et al. (2014) Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes Proceedings of the National Academy of Sciences of the United States of America. 111: 1168-1173
Napoli C, Paolisso G, Casamassimi A, et al. (2013) Effects of nitric oxide on cell proliferation: novel insights. Journal of the American College of Cardiology. 62: 89-95
Kwon KJ, Kim JN, Kim MK, et al. (2013) Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathway. Neurochemistry International. 62: 240-50
Zheng M, Kim SK, Joe Y, et al. (2012) Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity Faseb Journal. 26: 2558-2568
de Nigris F, Rienzo M, Sessa M, et al. (2012) Glycoxydation promotes vascular damage Via MAPK-ERK/JNK pathways Journal of Cellular Physiology. 227: 3639-3647
Ma L, Yang Y, Sikka SC, et al. (2012) Adipose tissue-derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction Proceedings of the National Academy of Sciences of the United States of America. 109: 2090-2095
Fukuto JM, Carrington SJ, Tantillo DJ, et al. (2012) Small molecule signaling agents: The integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species Chemical Research in Toxicology. 25: 769-793
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