Martin Eric Kuehne

Chemistry Univ. Vermont 
Synthetic Organic Chemistry, Alkaloids
"Martin Kuehne"
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Gilbert Stork grad student 1955 Columbia
 (Stereoselective routes to the diterpenoid resin acids)
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Antonio T, Childers SR, Rothman RB, et al. (2013) Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation. Plos One. 8: e77262
Kuehne ME, Waterman R. (2012) Rac-18-Meth-oxy-coronaridine hydro-chloride Acta Crystallographica Section E: Structure Reports Online. 68: o1041
Huang N, Jiang T, Wang T, et al. (2008) The acyclic dienamine-indoloacrylate addition route to catharanthine Tetrahedron. 64: 9850-9856
Pace CJ, Glick SD, Maisonneuve IM, et al. (2004) Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration. European Journal of Pharmacology. 492: 159-67
Kuehne ME, Bornmann WG, Markó I, et al. (2003) Syntheses and biological evaluation of vinblastine congeners Organic and Biomolecular Chemistry. 1: 2120-2136
Kuehne ME, He L, Jokiel PA, et al. (2003) Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. Journal of Medicinal Chemistry. 46: 2716-30
Chatterjee SK, Laffray J, Patel P, et al. (2002) Interaction of tubulin with a new fluorescent analogue of vinblastine Biochemistry. 41: 14010-14018
Gruol DJ, King MN, Kuehne ME. (2002) Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein Molecular Pharmacology. 62: 1238-1248
Delorenzi JC, Freire-de-Lima L, Gattass CR, et al. (2002) In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis Antimicrobial Agents and Chemotherapy. 46: 2111-2115
Zhang W, Ramamoorthy Y, Tyndale RF, et al. (2002) Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 663-9
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